公开(公告)号：US12209943B2

公开(公告)日：2025-01-28

申请号：US18567880

申请日：2022-09-16

Applicant: SHANDONG UNIVERSITY

Inventor： Lan Tian ,  Yanqing Wang ,  Jingjing Xu ,  Ming Zeng ,  Wei Liu ,  Xu Tian ,  Xiaoshan Lu

IPC: G01N15/1031 ,  G01N15/10

Abstract: An isolated cell membrane potential detection system can measure a cell membrane current change when light having different parameters such as wavelength, energy density, pulse width, and repetition rate stimulates a cell to be detected, to detect whether the biological electrical activity of the cell can be regulated by light, and to detect the specificity of the light regulation parameters of the cell. In the light regulation cell membrane potential detection system, a method of progressively adjusting and detecting with multiple optical parameters from small to large is used to measure a cell membrane current change in different periods under a certain photostimulation parameter for each group of cells, so as to quickly and efficiently detect which type of optical signal can regulate the characteristics of the cell such as the generation of a membrane current, photostimulation parameter specificity, and an energy threshold.