公开(公告)号：US12209943B2

公开(公告)日：2025-01-28

申请号：US18567880

申请日：2022-09-16

Applicant: SHANDONG UNIVERSITY

Inventor： Lan Tian ,  Yanqing Wang ,  Jingjing Xu ,  Ming Zeng ,  Wei Liu ,  Xu Tian ,  Xiaoshan Lu

IPC: G01N15/1031 ,  G01N15/10

Abstract: An isolated cell membrane potential detection system can measure a cell membrane current change when light having different parameters such as wavelength, energy density, pulse width, and repetition rate stimulates a cell to be detected, to detect whether the biological electrical activity of the cell can be regulated by light, and to detect the specificity of the light regulation parameters of the cell. In the light regulation cell membrane potential detection system, a method of progressively adjusting and detecting with multiple optical parameters from small to large is used to measure a cell membrane current change in different periods under a certain photostimulation parameter for each group of cells, so as to quickly and efficiently detect which type of optical signal can regulate the characteristics of the cell such as the generation of a membrane current, photostimulation parameter specificity, and an energy threshold.

公开(公告)号：US11123550B2

公开(公告)日：2021-09-21

申请号：US15575078

申请日：2016-12-01

Applicant: SHANDONG UNIVERSITY

Inventor： Lan Tian ,  Yong Wang ,  Xiaoshan Lu ,  Xu Tian

IPC: A61N1/05 ,  A61N1/36 ,  A61N1/372 ,  H04R25/00

Abstract: A cochlea electrode arrangement, system and method for enhancing musical melody perception. On each cochlear basilar membrane, according to the characteristic frequency correspondence of music notes, a phonosensitive full spectrum band corresponding to the cochlea apex to cochlea base is divided into musical response areas in response to specific musical note stimulating signals; a corresponding electrode for conducting or sensing frequency band signals is placed in each musical response area, namely, each electrode is placed in the corresponding characteristic frequency band where the music notes are located, the electrodes are divided into two groups, and a corresponding group of electrodes is implanted into cochleae on two sides respectively. Due to the fact that the electrodes are arranged in the cochleae on the two sides, the cochlea electrode arrangement is easy to implement, and the electrodes arranged in the cochleae on the two sides can perceive music better.