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公开(公告)号：US11883831B2
公开(公告)日：2024-01-30
申请号：US16603235
申请日：2017-04-06
Applicant: Shimadzu Corporation
Inventor： Masaki Kanai , Hiroyuki Jikuya , Tetsuo Ohashi , Seiya Fujiwara
IPC: B03C1/32 , C12Q1/68 , G01N35/08 , B01L3/00 , C12Q1/6806
CPC classification number: B03C1/32 , B01L3/502 , C12Q1/6806 , G01N35/08 , B01L2400/043
Abstract: A magnetic particle operation device comprising a tubular container having a longitudinal shape and including a sample introduction space in which a sample including a target substance and magnetic particles for immobilizing the target substance thereon are received, and a sample movement space in which a gel-like medium layer and a liquid layer are alternately arranged in its longitudinal direction. The magnetic particle operation device further comprising a first magnet provided outside the tubular container to face the sample introduction space, the first magnet configured to hold the magnetic particles in the sample introduction space in the container when the device is not used; and a second magnet configured to move the magnetic particles with the target substance being immobilized thereon, from the sample introduction space to the sample movement space, passing through the gel-like medium layer and the liquid layer in the longitudinal direction, when the device is used.
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公开(公告)号：US20170067923A1
公开(公告)日：2017-03-09
申请号：US15349807
申请日：2016-11-11
Applicant: SHIMADZU CORPORATION
Inventor： Tetsuo Ohashi
CPC classification number: G01N35/0098 , B01J2219/00364 , B01J2219/00466 , B01J2219/00468 , B01L3/5025 , B01L3/5082 , B01L2200/0647 , B01L2200/0673 , B01L2300/0832 , B01L2300/0861 , B01L2300/087 , B01L2400/043 , B03C1/00 , B03C1/12 , B03C1/288 , Y10T29/49826
Abstract: The present invention provides a small and low running-cost device capable of minimizing the generation of contamination sources as much as possible while performing a series of all the desired manipulations. A device for manipulating a target component in a manipulation tube, comprising: a manipulation tube comprising a tube having an optionally-closeable open end for supplying a sample containing a target component at one end and a closed end at the other end, and a manipulation medium accommodated in the tube and having a gel layer and an aqueous liquid layer multilayered in a longitudinal direction of the tube; magnetic particles that should transport the target component; and magnetic field applying means capable of applying a magnetic field to the manipulation tube to move the magnetic particles in the longitudinal direction of the tube.
Abstract translation: 本发明提供了一种小型和低运行成本的装置，其能够在执行一系列所有期望的操作的同时尽可能地最小化污染源的产生。 一种用于操纵操作管中的目标部件的装置，包括：操作管，其包括具有可选地可关闭的开口端的管，用于在一端提供含有目标部件的样品，在另一端封闭端，并且操作 介质容纳在管中并具有在管的纵向方向上多层的凝胶层和水性液体层; 应运送目标组分的磁性颗粒; 以及能够向操作管施加磁场以使磁性粒子沿着管的长度方向移动的磁场施加装置。
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公开(公告)号：US12163123B2
公开(公告)日：2024-12-10
申请号：US17292941
申请日：2018-11-22
Applicant: SHIMADZU CORPORATION
Inventor： Seiya Fujiwara , Masaki Kanai , Hiroyuki Jikuya , Tetsuo Ohashi , Masamitsu Shikata , Ayaka Minamimoto
Abstract: A purpose of the present invention is to suppress reduction in recovery rate of a target component due to a gel adhering to an inner wall surface of a treatment liquid layer. After passing magnetic particles through a gel layer, when moving the magnetic particles in the treatment liquid layer adjacent to the gel layer, the magnetic force source is automatically operated in a longitudinal direction of a tubular container so that the magnetic particles do not enter a range of a certain distance from the gel layer through which the magnetic particles have passed.
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公开(公告)号：US10384174B2
公开(公告)日：2019-08-20
申请号：US15526374
申请日：2014-11-17
Applicant: SHIMADZU CORPORATION , KAZUSA DNA RESEARCH INSTITUTE
Inventor： Jun Yanagibayashi , Tetsuo Ohashi , Osamu Ohara
IPC: B01F3/12 , B01J8/20 , B01F9/02 , B01J19/08 , B03C1/00 , B01F9/10 , B03C1/01 , B03C1/033 , B03C1/28 , C12M1/42 , B01F11/00 , B01F13/08
Abstract: The present invention relates to a particle manipulation method to disperse magnetic particles 70 in a liquid 35 filling up a tube container 10, wherein a circumferential direction moving step to move the magnetic particles 70 along the circumferential direction of the container 10 in the liquid 35 and in a radial direction moving step to move the magnetic particles 70 as crossing the radial direction of the container 10 in the liquid 35 are implemented repeatedly. Such manipulations can be achieved by combining rotation of the container and gravity force and magnetic field manipulations.
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公开(公告)号：US10073108B2
公开(公告)日：2018-09-11
申请号：US15349807
申请日：2016-11-11
Applicant: SHIMADZU CORPORATION
Inventor： Tetsuo Ohashi
CPC classification number: G01N35/0098 , B01J2219/00364 , B01J2219/00466 , B01J2219/00468 , B01L3/5025 , B01L3/5082 , B01L2200/0647 , B01L2200/0673 , B01L2300/0832 , B01L2300/0861 , B01L2300/087 , B01L2400/043 , B03C1/00 , B03C1/12 , B03C1/288 , Y10T29/49826
Abstract: The present invention provides a small and low running-cost device capable of minimizing the generation of contamination sources as much as possible while performing a series of all the desired manipulations. A device for manipulating a target component in a manipulation tube, comprising: a manipulation tube comprising a tube having an optionally-closeable open end for supplying a sample containing a target component at one end and a closed end at the other end, and a manipulation medium accommodated in the tube and having a gel layer and an aqueous liquid layer multilayered in a longitudinal direction of the tube; magnetic particles that should transport the target component; and magnetic field applying means capable of applying a magnetic field to the manipulation tube to move the magnetic particles in the longitudinal direction of the tube.
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Patent Agency Ranking
6.发明授权公开(公告)号：US10941394B2
公开(公告)日：2021-03-09
申请号：US15543425
申请日：2015-01-15
Applicant: SHIMADZU CORPORATION
Inventor： Masaki Kanai , Tetsuo Ohashi , Takahiro Nishimoto
Abstract: A device for manipulating magnetic particles includes a gelled medium layer and liquid layers alternately stacked in a tubular container along a longitudinal direction of the container. A magnetic particle movement portion for moving magnetic particles exists along an inner wall surface of the container, and the magnetic particle movement portion extends along the longitudinal direction of the container. At a portion where the gelled medium layer is loaded, the cross-sectional shape of the container inner wall in a plane perpendicular to the longitudinal direction of the container is non-circular, and the shape of the magnetic particle movement portion in the cross section is a curved shape or an angular shape.
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7.发明申请CHIP DEVICE FOR MANIPULATING OBJECT COMPONENT, AND METHOD USING THE SAME 有权用于操纵对象组件的芯片设备及使用该对象组件的方法公开(公告)号：US20140370511A1
公开(公告)日：2014-12-18
申请号：US14365104
申请日：2012-11-05
Applicant: SHIMADZU CORPORATION
Inventor： Isao Katasho , Tetsuo Ohashi
CPC classification number: C12Q1/6806 , B01L3/502707 , B01L3/502761 , B01L7/52 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/043 , G01N33/04 , G01N33/48707 , G01N35/0098 , H02K44/02 , Y10T29/49 , C12Q2565/629
Abstract: A chip device for manipulating an object component is described, in which multiple liquid substances such as reagents required for a series of manipulations on a sample are stably secured in separated states throughout the manipulations within the device. The chip device includes a manipulation chip, magnetic particles, and a magnetic field application means. The manipulation chip includes a substrate, a groove formed in the surface of the substrate, and a manipulation medium accommodated in the groove such that gel phases and aqueous liquid phases are alternately disposed in the longitudinal direction of the groove and are in contact with each other. The magnetic particles are for capturing and carrying the object component. The magnetic field application means is capable of moving the magnetic particles in the longitudinal direction of the groove in the substrate by the application of a magnetic field to the substrate.
Abstract translation: 描述了用于操纵对象部件的芯片装置，其中在装置内的整个操作中，以分离的状态稳定地确保多个液体物质，例如在样品上进行一系列操作所需的试剂。 芯片装置包括操纵芯片，磁性颗粒和磁场施加装置。 操作芯片包括基板，形成在基板的表面中的槽和容纳在槽中的操作介质，使得凝胶相和水相液相在槽的纵向交替地设置并且彼此接触 。 磁性颗粒用于捕获和携带物体成分。 磁场施加装置能够通过向衬底施加磁场而使衬底中的槽的纵向方向上的磁性颗粒移动。
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公开(公告)号：US09714445B2
公开(公告)日：2017-07-25
申请号：US14365104
申请日：2012-11-05
Applicant: SHIMADZU CORPORATION
Inventor： Isao Katasho , Tetsuo Ohashi
IPC: C12M1/00 , C12Q1/68 , H02K44/00 , H02K44/08 , H02K44/02 , G01N33/04 , G01N33/487 , B01L3/00 , B01L7/00 , G01N35/00
CPC classification number: C12Q1/6806 , B01L3/502707 , B01L3/502761 , B01L7/52 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/043 , G01N33/04 , G01N33/48707 , G01N35/0098 , H02K44/02 , Y10T29/49 , C12Q2565/629
Abstract: A chip device for manipulating an object component is described, in which multiple liquid substances such as reagents required for a series of manipulations on a sample are stably secured in separated states throughout the manipulations within the device. The chip device includes a manipulation chip, magnetic particles, and a magnetic field application means. The manipulation chip includes a substrate, a groove formed in the surface of the substrate, and a manipulation medium accommodated in the groove such that gel phases and aqueous liquid phases are alternately disposed in the longitudinal direction of the groove and are in contact with each other. The magnetic particles are for capturing and carrying the object component. The magnetic field application means is capable of moving the magnetic particles in the longitudinal direction of the groove in the substrate by the application of a magnetic field to the substrate.
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公开(公告)号：US09662663B2
公开(公告)日：2017-05-30
申请号：US14972102
申请日：2015-12-17
Applicant: SHIMADZU CORPORATION
Inventor： Masaki Kanai , Tetsuo Ohashi
CPC classification number: B03C1/288 , B01L3/502 , B01L9/06 , B01L2200/0668 , B01L2200/0673 , B01L2300/0832 , B01L2300/087 , B01L2400/043 , B03C1/0332 , B03C2201/18 , B03C2201/26 , G01N35/0098 , H01F7/0273
Abstract: The invention relates to a magnetic particle manipulation apparatus for moving magnetic particles within a tubular device, wherein the tubular device includes a gel-like medium layer and a liquid layer alternately stacked within a vessel and is filled with the magnetic particles. The magnetic particle manipulation apparatus of the invention includes a vessel holding portion, a vessel pressing portion and a magnetic field applying portion. The magnetic field applying portion includes a magnetic force source. At least one of the magnetic field applying portion and the vessel holding portion includes a moving mechanism capable of moving the magnetic force source. The vessel is pressed by the vessel pressing portion. The magnetic force source is moved relatively to the vessel holding portion by the moving mechanism, so as to move the magnetic particles.
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公开(公告)号：US09623410B2
公开(公告)日：2017-04-18
申请号：US14387116
申请日：2013-02-12
Applicant: SHIMADZU CORPORATION
Inventor： Tetsuo Ohashi
CPC classification number: B01L3/502 , B01L3/5021 , B01L3/502784 , B01L3/52 , B01L2200/0668 , B01L2200/0689 , B01L2300/0838 , B01L2300/0858 , B01L2300/087 , B01L2400/0409 , B01L2400/043 , B65D17/00 , B65D17/04 , G01N30/60 , Y10T156/1005
Abstract: Provided are a simple, quick, and low-processing cost method capable of reliably separating part of an accommodated substance accommodated in a vessel only by simple mechanical operation while maintaining a hermetically-sealed state without any contact with an outside atmosphere, as well as a vessel with which the method may be used. A separable vessel comprises a first vessel portion, a second vessel portion which is contiguous with the first vessel portion, a fracture-inducing portion formed between the first vessel portion and the second vessel portion, and a self-fusing material provided on an outer surface so as to cover the fracture-inducing portion; and may contain an accommodated substance therein.
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