公开(公告)号：US10400000B2

公开(公告)日：2019-09-03

申请号：US15735372

申请日：2016-06-13

Applicant: SIMON FRASER UNIVERSITY

Inventor： Marion Thévenin ,  Robert N. Young ,  Gang Chen

IPC: A61K47/30 ,  A61P19/08 ,  C07F9/572 ,  C07F9/38 ,  A61K47/54

Abstract: The present invention relates to conjugate compounds and methods of making and using same.

公开(公告)号：US09650414B1

公开(公告)日：2017-05-16

申请号：US14726020

申请日：2015-05-29

Applicant: Simon Fraser University

Inventor： Robert N. Young ,  Gang Chen ,  Haibo Xie

IPC: C07K5/06 ,  C07K5/062 ,  A61K38/00

CPC classification number: C07K5/06043 ,  A61K38/00 ,  A61K47/548

Abstract: The invention provides in part, compounds according to Formula I: and uses thereof.

公开(公告)号：US11312737B2

公开(公告)日：2022-04-26

申请号：US16518132

申请日：2019-07-22

Applicant: SIMON FRASER UNIVERSITY

Inventor： Marion Thévenin ,  Robert N. Young ,  Gang Chen

IPC: C07F9/572 ,  C07F9/38 ,  A61K47/54 ,  A61P19/08

Abstract: The present invention relates to EP4 agonist-bisphosphonate conjugates or related compounds and uses thereof. Said conjugates or related compounds may be used to provide delivery of an EP4 agonist or related compound to a desired site of action, such as a bone. Bisphosphonate moieties, linked to the EP4 agonists via amide linkers, have been implicated in the inhibition of bone resorption and bone targeting.

公开(公告)号：US09611284B2

公开(公告)日：2017-04-04

申请号：US13687762

申请日：2012-11-28

Applicant: Simon Fraser University

Inventor： Robert N. Young ,  Stephen Arns ,  Anne Moreau ,  Mohammed Monzur Morshed ,  Romelo Gibe

IPC: C07F9/572 ,  A61K47/48 ,  C07F9/6558 ,  C07F9/59 ,  C07F9/6512 ,  C07F9/38

CPC classification number: C07F9/572 ,  A61K47/548 ,  C07F9/3873 ,  C07F9/59 ,  C07F9/6512 ,  C07F9/65583

Abstract: The invention provides in part, conjugate compounds. The invention also provides synthesis methods for making the compounds, and uses of the compounds.

公开(公告)号：US10351527B2

公开(公告)日：2019-07-16

申请号：US15302363

申请日：2015-04-09

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  SIMON FRASER UNIVERSITY

Inventor： Paul Rennie ,  Artem Tcherkassov ,  Robert N. Young ,  Christophe M. Andre

IPC: C07D209/04 ,  C07D209/14 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07C243/22 ,  C07D209/08 ,  C07D209/10 ,  C07D209/30 ,  C07D209/34 ,  C07D209/42 ,  C07D235/18 ,  C07D235/30 ,  C07D277/82 ,  C07D401/06 ,  C07D401/10 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10

Abstract: This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.

公开(公告)号：US20130157984A1

公开(公告)日：2013-06-20

申请号：US13687762

申请日：2012-11-28

Applicant: Simon Fraser University

Inventor： Robert N. Young ,  Stephen Arns ,  Anne Moreau ,  Monzur Morshad ,  Romelo Gibe

IPC: C07F9/6558 ,  C07F9/572

CPC classification number: C07F9/572 ,  A61K47/548 ,  C07F9/3873 ,  C07F9/59 ,  C07F9/6512 ,  C07F9/65583

Abstract: The invention provides in part, conjugate compounds. The invention also provides synthesis methods for making the compounds, and uses of the compounds.

Abstract translation: 本发明部分提供了缀合物。 本发明还提供了制备该化合物的合成方法及其用途。