公开(公告)号：US20220282046A1

公开(公告)日：2022-09-08

申请号：US17605249

申请日：2019-10-25

Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGY

Inventor： Xiaoxi LI ,  Chengdeng CHI ,  Ling CHEN

IPC: C08G83/00 ,  C08B37/16

Abstract: The present disclosure belongs to the field of chemical industry production, and particularly relates to CD-MOFs and a preparation method thereof. The preparation method comprises the following steps: (1) formulating a supersaturated γ-cyclodextrin alkaline alcohol aqueous solution containing an alkali metal ion; (2) heating to obtain a hot γ-cyclodextrin solution; and (3) cooling the hot γ-cyclodextrin solution of the step (2), and performing crystallization and separation to obtain the cyclodextrin-based metal organic framework material. The CD-MOFs has perfect crystallization and large specific surface area, which are similar with those of a material prepared by means of traditional methods. The important thing is that the synthesis operation thereof is simple, green, and environmentally friendly, and the time required is shortened from a few hours or even tens of hours to a few minutes, which significantly improves the synthesis efficiency and is conductive to industrial scale production.

公开(公告)号：US20220249677A1

公开(公告)日：2022-08-11

申请号：US17621728

申请日：2019-11-28

Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGY

Inventor： Xiaoxi LI ,  Yiping ZHANG ,  Ling CHEN ,  Lin LI

IPC: A61K47/61 ,  C08B31/12

Abstract: Disclosed are a M-cell targeting and pH-responsive starch-based carrier material, and a preparation method and application thereof. The starch-based carrier material has a molecular structure as follows, a molecular weight of 7.04×104 to 2.11×106 g/mol, a degree of substitution of carboxymethyl groups of 0.04 to 0.28, and a grafting amount of targeting peptide GRGDS of 0.01% to 1.12% (calculated based on the content of N). The material is not dissolved in water when protonated at pH (pH=1.2) of the stomach, and is slowly dissolved in water when deprotonated at pH (pH=6.8) of the small intestine, therefore it has good responsiveness to pH of the gastrointestinal tract. The material can efficiently encapsulate a positively charged active substance by means of electrostatic interaction, therefore it can protect the active substances from being destroyed and inactivated in the gastrointestinal tract. Meanwhile, the material can target M cells to improve the transport efficiency of the active substance by M cells, thereby improving the bioavailability of the active substance.

公开(公告)号：US20180230239A1

公开(公告)日：2018-08-16

申请号：US15750512

申请日：2015-12-24

Applicant: SOUTH CHINA UNIVERSITY OF TECHNOLOGY

Inventor： Ling CHEN ,  Pingping BIE ,  Huayin PU ,  Xiaoxi LI ,  Binjia ZHANG

IPC: C08B30/12 ,  A23L5/30 ,  A23L29/212

CPC classification number: C08B30/12 ,  A23L5/30 ,  A23L29/212 ,  A23L29/219 ,  A23V2002/00

Abstract: A starch-based food thickener with low molecular weight and a preparation method thereof, comprising the steps of: adding starch powders with 5%-30% moisture content into an atmospheric pressure low-temperature dielectric barrier discharge plasma reactor, regulating the discharge gap to 0.2 mm-0.8 mm at atmospheric pressure, the discharge input voltage to 30 V-70 V, and the discharge current to 0.2 A-2.4 A, subjecting the materials in a fluidized state to plasma action in the circulating system by regulating the air flow rate with controlling time longer than 0.5 min, and then taking out the product after the completion of the reaction, i.e., to obtain a starch-based food thickener with low molecular weight. The method has such advantages as a simple technique involved, low cost, recyclable processing, large processing capacity, superior reaction uniformity, etc., and is also capable of efficiently and quickly degrading the molecular weight of starch, e.g., by 1-3 order(s) of magnitude within a short time. Moreover, the product has a superior transparency, retrogradation stability, and a certain thickening effect.