-
1.发明授权Polypeptide solution, artificial polypeptide fiber production method and polypeptide purification method using same 有权多肽溶液，人造多肽纤维生产方法和多肽纯化方法使用相同公开(公告)号：US09051453B2
公开(公告)日：2015-06-09
申请号：US14346893
申请日：2012-10-29
Applicant: SPIBER INC.
Inventor： Junichi Sugahara , Kazuhide Sekiyama , Ryota Sato , Kaori Sekiyama , Mizuki Ishikawa , Shinya Murata , Kazuko Otomo
CPC classification number: C08K5/41 , B29D99/0078 , C07K14/43518 , C08K3/16 , C08K5/20 , D01D5/04 , D01F4/02 , D01F6/68 , Y10S530/858
Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
Abstract translation: 本发明的多肽溶液是多肽溶液，其中衍生自天然蜘蛛丝蛋白的多肽溶解在溶剂中。 溶剂含有选自以下（i） - （iii）中的至少一种：（i）DMSO; （ii）具有无机盐的DMSO; 和（iii）具有无机盐的DMF。 此外，在本发明中，通过以下方式获得人造多肽纤维：使用多肽溶液作为掺杂溶液; 将喷丝头溶液从喷丝头挤出到去溶剂浴中，以从溶剂溶液中除去溶剂，并形成纤维以产生未拉伸的纱线。 此外，在本发明中，通过使多肽溶液进行热处理，然后从其中除去未溶解的物质来纯化多肽。 因此，本发明提供了溶质具有高溶解度且溶剂本身具有低成本且能够在高温下溶解并具有高安全性的多肽溶液。人造多肽纤维的制造方法以及纯化多肽的方法。
-
2.发明申请公开(公告)号：US20140245923A1
公开(公告)日：2014-09-04
申请号：US14346893
申请日：2012-10-29
Applicant: SPIBER INC.
Inventor： Junichi Sugahara , Kazuhide Sekiyama , Ryota Sato , Kaori Sekiyama , Mizuki Ishikawa , Shinya Murata , Kazuko Otomo
IPC: C08K5/41 , B29D99/00 , C08K3/16 , C07K14/435 , C08K5/16
CPC classification number: C08K5/41 , B29D99/0078 , C07K14/43518 , C08K3/16 , C08K5/20 , D01D5/04 , D01F4/02 , D01F6/68 , Y10S530/858
Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
Abstract translation: 本发明的多肽溶液是多肽溶液，其中衍生自天然蜘蛛丝蛋白的多肽溶解在溶剂中。 溶剂含有选自以下（i） - （iii）中的至少一种：（i）DMSO; （ii）具有无机盐的DMSO; 和（iii）具有无机盐的DMF。 此外，在本发明中，通过以下方式获得人造多肽纤维：使用多肽溶液作为掺杂溶液; 将喷丝头溶液从喷丝头挤出到去溶剂浴中，以从溶剂溶液中除去溶剂，并形成纤维以产生未拉伸的纱线。 此外，在本发明中，通过使多肽溶液进行热处理，然后从其中除去未溶解的物质来纯化多肽。 因此，本发明提供了溶质具有高溶解度且溶剂本身具有低成本且能够在高温下溶解并具有高安全性的多肽溶液。人造多肽纤维的制造方法以及纯化多肽的方法。
-
公开(公告)号：US09023142B2
公开(公告)日：2015-05-05
申请号：US14346893
申请日：2012-10-29
Applicant: Spiber Inc.
Inventor： Junichi Sugahara , Kazuhide Sekiyama , Ryota Sato , Kaori Sekiyama , Mizuki Ishikawa , Shinya Murata , Kazuko Otomo
Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
-
公开(公告)号：US08979992B2
公开(公告)日：2015-03-17
申请号：US14346893
申请日：2012-10-29
Applicant: Spiber Inc.
Inventor： Junichi Sugahara , Kazuhide Sekiyama , Ryota Sato , Kaori Sekiyama , Mizuki Ishikawa , Shinya Murata , Kazuko Otomo
Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
-
-
-
Search Results
4
records
(took 0.013 seconds)
