公开(公告)号：US3676299A

公开(公告)日：1972-07-11

申请号：US3676299D

申请日：1970-10-22

Applicant: SUN RESEARCH DEVELOPMENT

Inventor： RAYMOND RICHARD L

IPC: C07C59/90 ,  C07D311/66 ,  C12P7/42 ,  C12D1/00

CPC classification number: C07C59/90 ,  C07D311/66 ,  C12P7/42 ,  Y10S435/872 ,  Y10S435/886

Abstract: NOVEL HYDROXYPHENYLKETOBUTYRIC ACIDS HAVING THE STRUCTURAL FORMULA:

(2-HO,6-R3,R1,R2-PHENYL)-(CH2)2-CO-COOH

WHEREIN R1 AN R2 ARE HYDROGEN OR LOWER ALKYL GROUPS HAVING FROM ONE TO THREE CARBON ATOMS; R3 IS HYDROGEN, AND WHEREIN R1 AND R2 MAY BE THE SAME OR DIFFERENT, ARE PREPARED BY SUBJECTING NAPHTHALENE OR ALKYL-SUBSTITUTED NAPHTHALENES HAVING THE STRUCTURAL FORMULA:

1-R3,R1,R2-NAPHTHALENE

WHEREIN R1, R2 AND R3 ARE AS DEFINED ABOVE, TO THE OXIDIZING ACTIVITY OF THE MICROOGRANISMS NOCARDIA COELIACA, ATCC NO. 21,146, NOCARDIA NOV. SP., ATCC NO. 21,145, OR STREPTOMYCES SPECIES, ATCC NO. 21,147.