公开(公告)号：US20220267257A1

公开(公告)日：2022-08-25

申请号：US17393144

申请日：2021-08-03

Applicant: SpringWorks Therapeutics Inc.

Inventor： Kristin PATTERSON ,  Jiping LIU ,  Ricky Wayne COUCH ,  Peter Gregory VARLASHKIN ,  Mai LI ,  Yonghong GAN

IPC: C07C259/10 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48

Abstract: The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.

公开(公告)号：US20250025446A1

公开(公告)日：2025-01-23

申请号：US18908159

申请日：2024-10-07

Applicant: SpringWorks Therapeutics, Inc.

Inventor： Allison LIM ,  Shinta CHENG ,  Todd Webster SHEARER ,  Rex WILLIAMS ,  Kristin PATTERSON

IPC: A61K31/417 ,  A61K9/00 ,  A61P35/00

Abstract: The present disclosure relates to improved methods of treatment with nirogacestat.

公开(公告)号：US20240216307A1

公开(公告)日：2024-07-04

申请号：US18429056

申请日：2024-01-31

Applicant: SpringWorks Therapeutics, Inc.

Inventor： Kristin PATTERSON ,  Jiping LIU

IPC: A61K31/167 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20

CPC classification number: A61K31/167 ,  A61K9/0056 ,  A61K9/16 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2072

Abstract: The present disclosure relates to dispersible pharmaceutical compositions comprising N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, a pharmaceutically acceptable carrier.

公开(公告)号：US20240189282A1

公开(公告)日：2024-06-13

申请号：US18414185

申请日：2024-01-16

Applicant: SpringWorks Therapeutics, Inc.

Inventor： Allison LIM ,  Shinta CHENG ,  Todd Webster SHEARER ,  Rex WILLIAMS ,  Kristin PATTERSON

IPC: A61K31/417 ,  A61P35/00

CPC classification number: A61K31/417 ,  A61P35/00

Abstract: The present disclosure relates to improved methods of treatment with nirogacestat.

公开(公告)号：US20230089434A1

公开(公告)日：2023-03-23

申请号：US17929153

申请日：2022-09-01

Applicant: SPRINGWORKS THERAPEUTICS, INC.

Inventor： Kristin PATTERSON ,  Mark HATCHER

IPC: C07D233/88 ,  C07D263/44 ,  C07C227/26

Abstract: The present disclosures are directed to processes for synthesizing (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide (“nirogacestat”).

公开(公告)号：US20240217937A1

公开(公告)日：2024-07-04

申请号：US17995031

申请日：2022-09-08

Applicant: SpringWorks Therapeutics, Inc.

Inventor： Kristin PATTERSON ,  Mark HATCHER

IPC: C07D233/88 ,  A61K45/06

CPC classification number: C07D233/88 ,  A61K45/06

Abstract: The present disclosures are directed to chlorinated tetralin compounds and pharmaceutical compositions.

公开(公告)号：US20240190815A1

公开(公告)日：2024-06-13

申请号：US18413575

申请日：2024-01-16

Applicant: SpringWorks Therapeutics, Inc.

Inventor： Kristin PATTERSON ,  Jiping LIU ,  Ricky Wayne COUCH ,  Peter Gregory VARLASHKIN ,  Mai LI ,  Yonghong GAN

IPC: C07C259/10 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48

CPC classification number: C07C259/10 ,  A61K9/0095 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4866 ,  C07B2200/13

Abstract: The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.

公开(公告)号：US20240180874A1

公开(公告)日：2024-06-06

申请号：US18440869

申请日：2024-02-13

Applicant: SpringWorks Therapeutics, Inc.

Inventor： Allison LIM ,  Shinta CHENG ,  Todd Webster SHEARER ,  Rex WILLIAMS ,  Kristin PATTERSON

IPC: A61K31/417 ,  A61K9/00

CPC classification number: A61K31/417 ,  A61K9/0053

Abstract: The present disclosure relates to improved methods of treating ovarian cancer with nirogacestat.

公开(公告)号：US20230091415A1

公开(公告)日：2023-03-23

申请号：US17937283

申请日：2022-09-30

Applicant: SPRINGWORKS THERAPEUTICS, INC.

Inventor： Kristin PATTERSON ,  Mark HATCHER

IPC: C07D233/88

Abstract: The present disclosures are directed to processes for synthesizing (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide (“nirogacestat”).

公开(公告)号：US20230049311A1

公开(公告)日：2023-02-16

申请号：US17938590

申请日：2022-10-06

Applicant: SpringWorks Therapeutics, Inc.

Inventor： Shinta CHENG ,  Todd Webster SHEARER ,  Rex WILLIAMS ,  Kristin PATTERSON

IPC: C07D233/88

Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.