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公开(公告)号：US20240307328A1
公开(公告)日：2024-09-19
申请号：US18674104
申请日：2024-05-24
Applicant: SpringWorks Therapeutics, Inc.
Inventor： Uchenna H. ILOEJE , Abraham J. LANGSETH , Todd Webster SHEARER
IPC: A61K31/166 , A61K9/00 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
CPC classification number: A61K31/166 , A61K9/0053 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
Abstract: The present disclosure relates to a method for treating certain types of tumors or cancers, such as plexiform neurofibromas (PN), plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), by orally administering an effective amount of mirdametinib to the patient, where an amount of mirdametinib is administered on the first day of treatment to provide (i) an AUCO-tau less than 400 ng·h/mL, (ii) a Cmax no more than 40 ng/mL, or (iii) both.
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公开(公告)号：US20240216305A1
公开(公告)日：2024-07-04
申请号：US18609687
申请日：2024-03-19
Applicant: SpringWorks Therapeutics, Inc.
Inventor： Uchenna H. ILOEJE , Abraham J. LANGSETH , Todd Webster SHEARER
IPC: A61K31/166 , A61K9/00 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
CPC classification number: A61K31/166 , A61K9/0053 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
Abstract: The present disclosure relates to a method for treating certain types of tumors or cancers, such as plexiform neurofibromas (PN), plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), by orally administering an effective amount of mirdametinib to the patient, where an amount of mirdametinib is administered on the first day of treatment to provide (i) an AUC0-tau less than 400 ng·h/mL, (ii) a Cmax no more than 40 ng/ml, or (iii) both.
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公开(公告)号：US20250025446A1
公开(公告)日：2025-01-23
申请号：US18908159
申请日：2024-10-07
Applicant: SpringWorks Therapeutics, Inc.
Inventor： Allison LIM , Shinta CHENG , Todd Webster SHEARER , Rex WILLIAMS , Kristin PATTERSON
IPC: A61K31/417 , A61K9/00 , A61P35/00
Abstract: The present disclosure relates to improved methods of treatment with nirogacestat.
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公开(公告)号：US20240189282A1
公开(公告)日：2024-06-13
申请号：US18414185
申请日：2024-01-16
Applicant: SpringWorks Therapeutics, Inc.
Inventor： Allison LIM , Shinta CHENG , Todd Webster SHEARER , Rex WILLIAMS , Kristin PATTERSON
IPC: A61K31/417 , A61P35/00
CPC classification number: A61K31/417 , A61P35/00
Abstract: The present disclosure relates to improved methods of treatment with nirogacestat.
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公开(公告)号：US20240173274A1
公开(公告)日：2024-05-30
申请号：US18518127
申请日：2023-11-22
Applicant: SpringWorks Therapeutics Inc.
Inventor： Uchenna H. ILOEJE , Abraham J. LANGSETH , Todd Webster SHEARER
IPC: A61K31/166 , A61K9/00 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
CPC classification number: A61K31/166 , A61K9/0053 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
Abstract: The present disclosure relates to a method for treating certain types of tumors or cancers, such as plexiform neurofibromas (PN), plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), by orally administering an effective amount of mirdametinib to the patient, where an amount of mirdametinib is administered on the first day of treatment to provide (i) an AUC0-tau less than 400 ng·h/mL, (ii) a Cmax no more than 40 ng/mL, or (iii) both.
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Patent Agency Ranking
公开(公告)号：US20240307330A1
公开(公告)日：2024-09-19
申请号：US18674233
申请日：2024-05-24
Applicant: Springworks Therapeutics, Inc.
Inventor： Uchenna H. ILOEJE , Abraham J. LANGSETH , Todd Webster SHEARER
IPC: A61K31/166 , A61K9/00 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
CPC classification number: A61K31/166 , A61K9/0053 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
Abstract: The present disclosure relates to a method for treating certain types of tumors or cancers, such as plexiform neurofibromas (PN), plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), by orally administering an effective amount of mirdametinib to the patient, where an amount of mirdametinib is administered on the first day of treatment to provide (i) an AUC0-tau less than 400 ng·h/mL, (ii) a Cmax no more than 40 ng/mL, or (iii) both.
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公开(公告)号：US20240156784A1
公开(公告)日：2024-05-16
申请号：US18414147
申请日：2024-01-16
Applicant: SpringWorks Therapeutics, Inc.
Inventor： Allison LIM , Shinta CHENG , Todd Webster SHEARER , Rex WILLIAMS , Kristin PATTERSON
IPC: A61K31/417 , A61K9/00 , A61P43/00
CPC classification number: A61K31/417 , A61K9/0053 , A61P43/00
Abstract: The present disclosure relates to improved methods of treatment with nirogacestat.
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公开(公告)号：US20230087828A1
公开(公告)日：2023-03-23
申请号：US18049073
申请日：2022-10-24
Applicant: SpringWorks Therapeutics, Inc.
Inventor： Shinta CHENG , Todd Webster SHEARER , Rex WILLIAMS , Kristin PATTERSON
IPC: C07D233/88
Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof, and d) methods for the preparation of solid state forms of Compound 1.
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公开(公告)号：US20240226037A1
公开(公告)日：2024-07-11
申请号：US18609727
申请日：2024-03-19
Applicant: SpringWorks Therapeutics, Inc.
Inventor： Uchenna H. ILOEJE , Abraham J. LANGSETH , Todd Webster SHEARER
IPC: A61K31/166 , A61K9/00 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
CPC classification number: A61K31/166 , A61K9/0053 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
Abstract: The present disclosure relates to a method for treating certain types of tumors or cancers, such as plexiform neurofibromas (PN), plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), by orally administering an effective amount of mirdametinib to the patient, where an amount of mirdametinib is administered on the first day of treatment to provide (i) an AUC0-tau less than 400 ng·h/mL, (ii) a Cmax no more than 40 ng/ml, or (iii) both.
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公开(公告)号：US20240216306A1
公开(公告)日：2024-07-04
申请号：US18609768
申请日：2024-03-19
Applicant: SpringWorks Therapeutics Inc.
Inventor： Uchenna H. ILOEJE , Abraham J. LANGSETH , Todd Webster SHEARER
IPC: A61K31/166 , A61K9/00 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
CPC classification number: A61K31/166 , A61K9/0053 , A61K31/216 , A61K45/06 , A61P25/00 , A61P35/00
Abstract: The present disclosure relates to a method for treating certain types of tumors or cancers, such as plexiform neurofibromas (PN), plexiform neurofibromas associated with neurofibromatosis type 1 (NF1-PN), by orally administering an effective amount of mirdametinib to the patient, where an amount of mirdametinib is administered on the first day of treatment to provide (i) an AUC0-tau less than 400 ng·h/mL, (ii) a Cmax no more than 40 ng/ml, or (iii) both.
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