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1.发明申请公开(公告)号：US20140102901A1
公开(公告)日：2014-04-17
申请号：US14042585
申请日：2013-09-30
Inventor： Mehdi Javanmard , Sam Emaminejad , Janine Mok , Michael N. Mindrinos
CPC classification number: B03C7/023 , B03C5/005 , B03C5/026 , B03C2201/26 , B81B1/006
Abstract: The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components.
Abstract translation: 介电电泳（介电电泳或DEP）的过程利用在施加正（有吸引力）和/或负（排斥）施加力的情况下移动的场极化粒子。 本发明在微通道分离装置内使用负电介质电泳（负介电电泳或nDEP）来使颗粒移动（分离）或保持静止（附着）。 在本发明的一个实施方案中，所产生的nDEP力足够强大以分离出约400pN（piconewtons）的Ag-Ab（抗原 - 抗体）键，同时保持系统组分的完整性。
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公开(公告)号：US10585096B2
公开(公告)日：2020-03-10
申请号：US15031793
申请日：2014-10-24
Inventor： Sam Emaminejad , Mehdi Javanmard , Chaitanya Gupta , Roger T. Howe
IPC: G01N33/543
Abstract: Embodiments of the present disclosure provide for systems of enhancing the signal to noise ratio, methods of orienting a nanomaterial (e.g., an antibody), methods of enhancing the signal to noise ratio in a system (e.g., an assay system), and the like.
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公开(公告)号：US20180070870A1
公开(公告)日：2018-03-15
申请号：US15700119
申请日：2017-09-09
Applicant: The Board of Trustees of the Leland Stanford Junior University , The Regents of the University of California
Inventor： Sam Emaminejad , Carlos Milla , Wei Gao , Ali Javey , Eric Wu , Ronald W. Davis
IPC: A61B5/145 , A61B5/1477
CPC classification number: A61B5/14521 , A61B5/14514 , A61B5/14532 , A61B5/1477 , A61B5/4266
Abstract: A device for on-demand sweat extraction and analysis is realized as a printed circuit comprising a microcontroller, an iontophoresis circuit, a sensing circuit, and an electrode array having iontophoresis electrodes for sweat induction and sensing electrodes connected for sweat sensing. The sensing electrodes are positioned between the iontophoresis electrodes. The iontophoresis electrodes are preferably crescent-shaped and comprise a layer of agonist agent hydrogel loaded with sweat stimulating compounds. The iontophoresis circuit has a programmable current source for iontophoresis current delivery, and the sensing circuit includes two signal conditioning paths, where each of the paths includes an analog front-end to amplify a sensed signal and a low-pass filter to minimize high frequency noise and electromagnetic interference. The iontophoresis circuit and the sensing circuit are electrically decoupled for independent functionality.
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公开(公告)号：US09981273B2
公开(公告)日：2018-05-29
申请号：US14042585
申请日：2013-09-30
Inventor： Mehdi Javanmard , Sam Emaminejad , Janine Mok , Michael N. Mindrinos
CPC classification number: B03C7/023 , B03C5/005 , B03C5/026 , B03C2201/26 , B81B1/006
Abstract: The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components.
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