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公开(公告)号：US20170029461A1
公开(公告)日：2017-02-02
申请号：US15112984
申请日：2015-01-20
Inventor： Suresh Kumar Thallapuranam , Srinivas Jayanthi , Jacqueline Morris , Alicia Brown , David McNabb , Ralph Henry
IPC: C07K1/22 , C12N9/64 , B01D15/38 , B01J20/28 , B01D69/08 , B01D15/22 , B01J20/286 , C07K14/00 , B01D15/20
CPC classification number: C07K1/22 , B01D15/206 , B01D15/22 , B01D15/3809 , B01D69/08 , B01J20/28078 , B01J20/286 , C07K14/00 , C07K2319/20 , C07K2319/50 , C12N9/6424 , C12Y304/21043
Abstract: In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino acid sequence including a repeating amino acid unit of BXXXBXX, wherein B is an amino acid selected from the group consisting of histidine, lysine and arginine and X is an amino acid selected from the group consisting of amino acids other than histidine, lysine and arginine.
Abstract translation: 一方面，本文描述了用于重组蛋白质纯化的亲和标签，其在一些实施方案中可以减轻或克服先前亲和标签系统的缺点。 在一些实施方案中，例如，本文所述的亲和标签允许用简化的溶液系统（例如碱金属盐溶液）有效洗脱所需重组蛋白。 本文所述的亲和标签包含包含BXXXBXX的重复氨基酸单元的氨基酸序列，其中B是选自组氨酸，赖氨酸和精氨酸的氨基酸，X是选自氨基酸 除了组氨酸，赖氨酸和精氨酸。
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公开(公告)号：US20190284252A1
公开(公告)日：2019-09-19
申请号：US16356872
申请日：2019-03-18
Inventor： Suresh Kumar Thallapuranam , Shilpi Agarwal , Ravi Kumar Gindampati , Srinivas Jayanthi , Tengjiao Wang , Jake Jones , Olivia Kolenc , Ngoc Lam , Isabelle Niyonshuti , Kartik Balachandran , Kyle Quinn , Jingyi Chen
Abstract: Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.
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公开(公告)号：US09676816B2
公开(公告)日：2017-06-13
申请号：US14378230
申请日：2014-01-21
Inventor： Suresh Kumar Thallapuranam , Srinivas Jayanthi , Jacqueline Morris , Alicia Brown , David McNabb , Ralph Henry
IPC: C12N9/64 , C07K14/00 , C07K1/22 , B01D15/20 , B01D15/22 , B01D15/38 , B01D69/08 , B01J20/28 , B01J20/286
CPC classification number: C07K1/22 , B01D15/206 , B01D15/22 , B01D15/3809 , B01D69/08 , B01J20/28078 , B01J20/286 , C07K14/00 , C07K2319/20 , C07K2319/50 , C12N9/6424 , C12Y304/21043
Abstract: In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino acid sequence including a repeating amino acid unit of BXXXBXX, wherein B is an amino acid selected from the group consisting of histidine, lysine and arginine and X is an amino acid selected from the group consisting of amino acids other than histidine, lysine and arginine.
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公开(公告)号：US20160145597A1
公开(公告)日：2016-05-26
申请号：US14378230
申请日：2014-01-21
Inventor： Suresh Kumar Thallapuranam , Srinivas Jayanthi , Jacqueline Morris , Alicia Brown , David McNabb , Ralph Henry
CPC classification number: C07K1/22 , B01D15/206 , B01D15/22 , B01D15/3809 , B01D69/08 , B01J20/28078 , B01J20/286 , C07K14/00 , C07K2319/20 , C07K2319/50 , C12N9/6424 , C12Y304/21043
Abstract: In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino acid sequence including a repeating amino acid unit of BXXXBXX, wherein B is an amino acid selected from the group consisting of histidine, lysine and arginine and X is an amino acid selected from the group consisting of amino acids other than histidine, lysine and arginine.
Abstract translation: 一方面，本文描述了用于重组蛋白质纯化的亲和标签，其在一些实施方案中可以减轻或克服先前亲和标签系统的缺点。 在一些实施方案中，例如，本文所述的亲和标签允许用简化的溶液系统（例如碱金属盐溶液）有效洗脱所需重组蛋白。 本文所述的亲和标签包含包含BXXXBXX的重复氨基酸单元的氨基酸序列，其中B是选自组氨酸，赖氨酸和精氨酸的氨基酸，X是选自氨基酸 除了组氨酸，赖氨酸和精氨酸。
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Patent Agency Ranking
公开(公告)号：US20220227826A1
公开(公告)日：2022-07-21
申请号：US17587889
申请日：2022-01-28
Inventor： Suresh Kumar Thallapuranam , Shilpi Agrawal , Ravi Kumar Gundampati , Srinivas Jayanthi , Tengjiao Wang , Jake Jones , Olivia Kolenc , Ngoc Lam , Isabelle Niyonshuti , Kartik Balachandran , Kyle Quinn , Jingyi Chen
Abstract: Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.
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公开(公告)号：US11267855B2
公开(公告)日：2022-03-08
申请号：US16356872
申请日：2019-03-18
Inventor： Suresh Kumar Thallapuranam , Shilpi Agarwal , Ravi Kumar Gundampati , Srinivas Jayanthi , Tengjiao Wang , Jake Jones , Olivia Kolenc , Ngoc Lam , Isabelle Niyonshuti , Kartik Balachandran , Kyle Quinn , Jingyi Chen
Abstract: Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.
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公开(公告)号：US10385113B2
公开(公告)日：2019-08-20
申请号：US15474268
申请日：2017-03-30
Inventor： Suresh Kumar Thallapuranam , David A. Zaharoff , Srinivas Jayanthi , Bhanuprasanth Koppolu , Rebecca Kerr , Kartik Balachandran , David S. McNabb
Abstract: The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.
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公开(公告)号：US10280196B2
公开(公告)日：2019-05-07
申请号：US15112984
申请日：2015-01-20
Inventor： Suresh Kumar Thallapuranam , Srinivas Jayanthi , Jacqueline Morris , Alicia Brown , David McNabb , Ralph Henry
IPC: C07K1/22 , B01J20/286 , B01J20/28 , B01D69/08 , B01D15/38 , B01D15/22 , B01D15/20 , C07K14/00 , C12N9/64
Abstract: In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino acid sequence including a repeating amino acid unit of BXXXBXX, wherein B is an amino acid selected from the group consisting of histidine, lysine and arginine and X is an amino acid selected from the group consisting of amino acids other than histidine, lysine and arginine.
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公开(公告)号：US20170106092A1
公开(公告)日：2017-04-20
申请号：US15315097
申请日：2015-06-01
Inventor： David A. Zaharoff , Suresh Kumar Thallapuranam , Bhanu prasanth Koppolu , Srinivas Jayanthi , Sean G. Smith
CPC classification number: A61K38/208 , A61K39/39 , A61K45/06 , A61K47/61 , A61K47/62 , A61K2039/6087
Abstract: Compositions including chitosan covalently linked to a cytokine or growth factor are provided herein. The compositions can be used to produce pharmaceutical compositions and can be used in methods of treating a variety of diseases or disorders. The compositions are especially suitable for localized delivery and may allow for intratamoral delivery and treatment of cancers or stimulation of an immune response to a co-administered antigen.
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