公开(公告)号：US20160244714A1

公开(公告)日：2016-08-25

申请号：US15029789

申请日：2014-10-20

Applicant: THE GENERAL HOSPTIAL CORPORATION

Inventor： Philipp S. Spuhler ,  Kyle C. Smith ,  Fabio Fachin ,  Thomas Alan Barber ,  Ravi Kapur ,  Mehmet Toner ,  Vincent Pai ,  Murat N. Karabacak

IPC: C12M1/00 ,  B03C1/033 ,  C12M3/06 ,  B03C1/01

CPC classification number: C12M47/04 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/043 ,  B01L2400/0487 ,  B01L2400/086 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  C12M23/16 ,  G01N15/1463 ,  G01N35/0098 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2035/00237 ,  G01N2035/1034

Abstract: Microfluidic devices are described that include a microfluidic channel, a first array of one or more magnets above the microfluidic channel, each magnet in the first array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the first array, and a second array of one or more magnets beneath the microfluidic channel, each magnet in the second array having a magnetic pole orientation opposite to a magnetic pole orientation of an adjacent magnet in the second array. The first array is aligned with respect to the second array such that magnetic fields emitted by the first array and second array generate a magnetic flux gradient profile extending through the channel. An absolute value of the profile includes a first maximum and a second maximum that bound a local minimum. The local minimum is located within the microfluidic channel or less than 5 mm away from a wall of the microfluidic channel. Methods of using the new devices are also described.

Abstract translation: 描述了微流体装置，其包括微流体通道，位于微流体通道上方的一个或多个磁体的第一阵列，第一阵列中的每个磁体具有与第一阵列中的相邻磁体的磁极取向相反的磁极取向，以及 在微流体通道下方的一个或多个磁体的第二阵列，第二阵列中的每个磁体具有与第二阵列中的相邻磁体的磁极取向相反的磁极取向。 第一阵列相对于第二阵列对齐，使得由第一阵列和第二阵列发射的磁场产生延伸穿过通道的磁通梯度分布。 轮廓的绝对值包括限制局部最小值的第一最大值和第二最大值。 局部最小值位于微流体通道内，或距离微流体通道的壁少于5毫米。 还描述了使用新装置的方法。