公开(公告)号：US09772280B2

公开(公告)日：2017-09-26

申请号：US14760817

申请日：2014-01-13

Applicant: The Regents of the University of California

Inventor： Albert Cerussi ,  Bruce Tromberg ,  Keun-sik No ,  Brian Hill ,  Pai Chou

IPC: A61B6/00 ,  G01N21/47 ,  A61B5/00 ,  G01N21/31 ,  G01N21/49 ,  G01J3/02

CPC classification number: G01N21/47 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/7225 ,  G01J3/0264 ,  G01J3/0272 ,  G01N21/3103 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/4735 ,  G01N2021/4797

Abstract: A diffuse optical spectroscopic imaging (DOSI) apparatus for tissue spectroscopy measures absorption and scattering properties of tissue using multi-frequency frequency domain photon migration in a modular or networkable platform to provide full broadband information content. The apparatus includes: a broadband signal generator; a driver having an input coupled to the signal generator; a light source coupled to the driver, the light source for exposing the tissue to broadband modulated light at a plurality of wavelengths; an optical detector for receiving returned light from the tissue; an amplitude detection circuit communicated to the optical detector; a phase detection circuit communicated to the optical detector; and a plurality of filters and amplifiers, wherein the optical detector, amplitude detection circuit and phase detection circuit are interconnected with each other by corresponding ones of the plurality of filters and amplifiers to isolate signals and increase signal-to-noise ratio.

公开(公告)号：US20150351635A1

公开(公告)日：2015-12-10

申请号：US14760817

申请日：2014-01-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Albert Cerussi ,  Bruce Tromberg ,  Keun-sik No ,  Brian Hill ,  Pai Chou

IPC: A61B5/00 ,  G01N21/49 ,  G01N21/31

CPC classification number: G01N21/47 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/7225 ,  G01J3/0264 ,  G01J3/0272 ,  G01N21/3103 ,  G01N21/4795 ,  G01N21/49 ,  G01N2021/4735 ,  G01N2021/4797

Abstract: A diffuse optical spectroscopic imaging (DOSI) apparatus for tissue spectroscopy measures absorption and scattering properties of tissue using multi-frequency frequency domain photon migration in a modular or networkable platform to provide full broadband information content. The apparatus includes: a broadband signal generator; a driver having an input coupled to the signal generator; a light source coupled to the driver, the light source for exposing the tissue to broadband modulated light at a plurality of wavelengths; an optical detector for receiving returned light from the tissue; an amplitude detection circuit communicated to the optical detector; a phase detection circuit communicated to the optical detector; and a plurality of filters and amplifiers, wherein the optical detector, amplitude detection circuit and phase detection circuit are interconnected with each other by corresponding ones of the plurality of filters and amplifiers to isolate signals and increase signal-to-noise ratio.

Abstract translation: 用于组织光谱的漫射光谱成像（DOSI）装置在模块化或可联网的平台中使用多频率频域光子迁移来测量组织的吸收和散射性质，以提供完整的宽带信息内容。 该装置包括：宽带信号发生器; 具有耦合到所述信号发生器的输入的驱动器; 耦合到驱动器的光源，用于将组织暴露于多个波长的宽带调制光的光源; 用于接收来自组织的返回光的光学检测器; 振幅检测电路，传送到光检测器; 通信给光检测器的相位检测电路; 以及多个滤波器和放大器，其中光检测器，振幅检测电路和相位检测电路通过多个滤波器和放大器中的相应的滤波器和放大器彼此互连，以隔离信号并提高信噪比。