公开(公告)号：US20220236109A1

公开(公告)日：2022-07-28

申请号：US17723817

申请日：2022-04-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Enrico Gratton ,  Alexander Dvornikov

IPC: G01J3/28 ,  G01N21/64 ,  G01J3/44 ,  H04N9/04 ,  H04N5/235

Abstract: An imaging system comprises an excitation light source, a directing element positioned to direct light from the excitation light source toward a sample, a detector configured to measure incoming light from the sample, a filter cavity positioned between the sample and the detector, a first filter configured to be inserted into the filter cavity, a sine filter configured to be inserted into the filter cavity, and a processing unit communicatively connected to the detector, configured to receive image data from the detector to form an image. Methods of constructing a hyperspectral image of a sample are also described.

公开(公告)号：US20200378830A1

公开(公告)日：2020-12-03

申请号：US16886092

申请日：2020-05-28

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Enrico Gratton ,  Alexander Dvornikov

IPC: G01J3/28 ,  G01N21/64 ,  G01J3/44 ,  H04N9/04 ,  H04N5/235

Abstract: An imaging system comprises an excitation light source, a directing element positioned to direct light from the excitation light source toward a sample, a detector configured to measure incoming light from the sample, a filter cavity positioned between the sample and the detector, a first filter configured to be inserted into the filter cavity, a sine filter configured to be inserted into the filter cavity, and a processing unit communicatively connected to the detector, configured to receive image data from the detector to form an image. Methods of constructing a hyperspectral image of a sample are also described.

公开(公告)号：US12281941B2

公开(公告)日：2025-04-22

申请号：US17723817

申请日：2022-04-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Enrico Gratton ,  Alexander Dvornikov

IPC: G01J3/28 ,  G01J3/44 ,  G01N21/64 ,  H04N23/72 ,  H04N25/13

Abstract: An imaging system comprises an excitation light source, a directing element positioned to direct light from the excitation light source toward a sample, a detector configured to measure incoming light from the sample, a filter cavity positioned between the sample and the detector, a first filter configured to be inserted into the filter cavity, a sine filter configured to be inserted into the filter cavity, and a processing unit communicatively connected to the detector, configured to receive image data from the detector to form an image. Methods of constructing a hyperspectral image of a sample are also described.

公开(公告)号：US09874736B2

公开(公告)日：2018-01-23

申请号：US13873159

申请日：2013-04-29

Applicant: The Regents of the University of California

Inventor： Francesco Cutrale ,  Enrico Gratton

IPC: G02B21/16

CPC classification number: G02B21/16 ,  G02B2207/113

Abstract: An apparatus for inclined single plane Illumination microscopy of a sample includes a laser for launching excitation light beams at a plurality of wavelengths, a laser beam expander, an injection arm optically coupled to the laser beam expander, a conventional back-to-back microscope system, a universal dichroic mirror optically coupled to the injection arm to direct the excitation light beams into the conventional back-to-back microscope onto a sample plane in an imaging plane, and to receive fluorescence light from the sample, a universal optical adaptor optically coupled to the universal dichroic mirror, a re-imaging component optically coupled to the universal optical adaptor; and a camera output connector optically coupled to the re-imaging component, where the laser beam expander, injection arm, universal optical adapter, re-imaging component, and camera are combined in a modular unit which is arranged and configured to be coupled to the conventional back-to-back microscope.

公开(公告)号：US11307094B2

公开(公告)日：2022-04-19

申请号：US16886092

申请日：2020-05-28

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Enrico Gratton ,  Alexander Dvornikov

IPC: G01J3/28 ,  G01N21/64 ,  G01J3/44 ,  H04N9/04 ,  H04N5/235

Abstract: An imaging system comprises an excitation light source, a directing element positioned to direct light from the excitation light source toward a sample, a detector configured to measure incoming light from the sample, a filter cavity positioned between the sample and the detector, a first filter configured to be inserted into the filter cavity, a sine filter configured to be inserted into the filter cavity, and a processing unit communicatively connected to the detector, configured to receive image data from the detector to form an image. Methods of constructing a hyperspectral image of a sample are also described.

公开(公告)号：US20140320601A1

公开(公告)日：2014-10-30

申请号：US13873159

申请日：2013-04-29

Applicant: The Regents of the University of California

Inventor： Francesco Cutrale ,  Enrico Gratton

IPC: H04N13/02

CPC classification number: G02B21/16 ,  G02B2207/113

Abstract: An apparatus for inclined single plane Illumination microscopy of a sample includes a laser for launching excitation light beams at a plurality of wavelengths, a laser beam expander, an injection arm optically coupled to the laser beam expander, a conventional back-to-back microscope system, a universal dichroic mirror optically coupled to the injection arm to direct the excitation light beams into the conventional back-to-back microscope onto a sample plane in an imaging plane, and to receive fluorescence light from the sample, a universal optical adaptor optically coupled to the universal dichroic mirror, a re-imaging component optically coupled to the universal optical adaptor; and a camera output connector optically coupled to the re-imaging component, where the laser beam expander, injection arm, universal optical adapter, re-imaging component, and camera are combined in a modular unit which is arranged and configured to be coupled to the conventional back-to-back microscope.

Abstract translation: 用于倾斜单平面的装置样品的照明显微镜包括用于发射多个波长的激发光束的激光器，激光束扩展器，与激光束扩展器光学耦合的注入臂，常规的背对背显微镜系统 光学耦合到注射臂的通用二向色镜，以将激发光束引导到常规的背对背显微镜到成像平面中的采样平面上，并且从样品接收荧光;光学耦合的通用光学适配器 到通用分色镜，光学耦合到通用光学适配器的再成像组件; 以及光学耦合到重新成像组件的相机输出连接器，其中激光束扩展器，注入臂，通用光学适配器，重新成像部件和相机被组合在模块化单元中，该模块单元被布置和配置为耦合到 常规的背对背显微镜。