公开(公告)号：US20170350803A1

公开(公告)日：2017-12-07

申请号：US15672051

申请日：2017-08-08

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Eric Diebold ,  Brandon Buckley

IPC: G01N15/14 ,  G01N21/64 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/537 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2021/6421 ,  G01N2201/067

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

公开(公告)号：US09784661B2

公开(公告)日：2017-10-10

申请号：US15263419

申请日：2016-09-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Bahram Jalali ,  Eric Diebold ,  Brandon Buckley

IPC: G01N15/14 ,  G01N21/64 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/537 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2021/6421 ,  G01N2201/067

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

公开(公告)号：US10222316B2

公开(公告)日：2019-03-05

申请号：US16019323

申请日：2018-06-26

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Eric Diebold ,  Brandon Buckley

IPC: G01N21/64 ,  G01N15/14 ,  G01N33/537 ,  G01N15/10

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

公开(公告)号：US20180364146A1

公开(公告)日：2018-12-20

申请号：US16019323

申请日：2018-06-26

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Eric Diebold ,  Brandon Buckley

IPC: G01N15/14 ,  G01N21/64 ,  G01N33/537 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/537 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2021/6421 ,  G01N2201/067

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

公开(公告)号：US20190145882A1

公开(公告)日：2019-05-16

申请号：US16247426

申请日：2019-01-14

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Eric Diebold ,  Brandon Buckley

IPC: G01N15/14 ,  G01N21/64 ,  G01N33/537

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/537 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2021/6421 ,  G01N2201/067

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

公开(公告)号：US20170227444A1

公开(公告)日：2017-08-10

申请号：US15263419

申请日：2016-09-13

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Bahram Jalai ,  Eric Diebold ,  Brandon Buckley

IPC: G01N15/14 ,  G01N21/64

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/537 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2021/6421 ,  G01N2201/067

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

公开(公告)号：US10451538B2

公开(公告)日：2019-10-22

申请号：US16247426

申请日：2019-01-14

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Eric Diebold ,  Brandon Buckley

IPC: G01N15/10 ,  G01N15/14 ,  G01N33/537 ,  G01N21/64

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.

公开(公告)号：US10036699B2

公开(公告)日：2018-07-31

申请号：US15672051

申请日：2017-08-08

Applicant: The Regents of the University of California

Inventor： Bahram Jalali ,  Eric Diebold ,  Brandon Buckley

IPC: G01N15/14 ,  G01N21/64 ,  G01N15/10

CPC classification number: G01N15/1434 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/537 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2021/6421 ,  G01N2201/067

Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.