公开(公告)号：US12071664B2

公开(公告)日：2024-08-27

申请号：US17939760

申请日：2022-09-07

Applicant: Pacific Biosciences of California, Inc.

Inventor： Adrian Fehr ,  Nathaniel Joseph McCaffrey ,  Stephen Turner

IPC: C12Q1/6874 ,  B01L3/00 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/05 ,  G01N21/64 ,  G01N21/75 ,  G01N21/77 ,  G01N33/543 ,  G02B6/122

CPC classification number: C12Q1/6874 ,  B01L3/502707 ,  B01L3/502715 ,  B82Y20/00 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/64 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/6456 ,  G01N21/648 ,  G01N21/75 ,  G01N21/77 ,  G01N33/54373 ,  G02B6/1226 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/168 ,  G01N2021/0346 ,  G01N2021/6434 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/757 ,  G01N2021/7786 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/08 ,  Y10T436/143333

Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.

公开(公告)号：US20240272066A1

公开(公告)日：2024-08-15

申请号：US18438513

申请日：2024-02-11

Applicant: Zhenhong Yu ,  James William Assif

Inventor： Zhenhong Yu ,  James William Assif

IPC: G01N21/17

CPC classification number: G01N21/1702 ,  G01N2201/067 ,  G01N2201/0691

Abstract: The present disclosure is directed to a photoacoustic excitation device comprising an amplitude modulator to control emitted light beam.

公开(公告)号：US20190170649A1

公开(公告)日：2019-06-06

申请号：US16210311

申请日：2018-12-05

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Yuichi WAKAMOTO ,  Koseki KOBAYASHI

IPC: G01N21/65 ,  G01J3/44 ,  G01L1/24 ,  C12Q1/6816

CPC classification number: G01N21/65 ,  C12Q1/6816 ,  G01J3/44 ,  G01L1/242 ,  G01N2021/0143 ,  G01N2201/067

Abstract: An objective cell is irradiated with laser beam of a predetermined wavelength. Only Stokes light is selected out of detected light including reflected light and scattered light of the laser beam, and a Raman scattering spectrum is obtained by dispersion of the selected Stokes light. A transcriptome of the objective cells is estimated, based on the Raman scattering spectrum. It is preferable to estimate the transcriptome of the objective cells, based on N-dimensional Raman data obtained by dimensional reduction of the Raman scattering spectrum. This configuration only needs to irradiate the objective cell with the laser beam and does not require to destroy the objective cell. As a result, this enables the transcriptome of the cell to be estimated in a short time period without destroying the cell.

公开(公告)号：US20170285063A1

公开(公告)日：2017-10-05

申请号：US15485261

申请日：2017-04-12

Applicant: United States of America, as represented by the Secretary of the Army

Inventor： Bradley W. Libbey ,  James D. Perea

IPC: G01P3/36

CPC classification number: G01P3/36 ,  G01H9/00 ,  G01H9/002 ,  G01N21/1702 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/0683 ,  G01N2201/12

Abstract: A laboratory system has demonstrated the measurement of three degrees of vibrational freedom simultaneously using a single beam through heterodyne speckle imaging. The random interference pattern generated by the illumination of a rough surface with coherent light can be exploited to extract information about the surface motion. The optical speckle pattern is heterodyne mixed with a coherent reference. The recorded optical data is then processed to extract three dimensions of surface motion. Axial velocity is measured by demodulating the received time-varying intensity of high amplitude pixels. Tilt, a gradient of surface velocity, is calculated by measuring speckle translation following reconstruction of the speckle pattern from the mixed signal.

公开(公告)号：US09702812B2

公开(公告)日：2017-07-11

申请号：US14706743

申请日：2015-05-07

Applicant: Theodore Peter Rakitzis

Inventor： Theodore Peter Rakitzis

IPC: G01N21/19 ,  G01J4/02 ,  G01J4/04 ,  G01N21/21 ,  G01J4/00

CPC classification number: G01N21/19 ,  G01J4/02 ,  G01J4/04 ,  G01J2004/001 ,  G01N21/21 ,  G01N2201/06113 ,  G01N2201/0636 ,  G01N2201/067

Abstract: A polarimeter for measuring chirality of a material comprising an optical ring cavity comprising a plurality of reflective elements configured to promote bi-directional propagation of a laser beam within the cavity, a laser-emitting device configured to introduce a first input laser beam and a second input laser beam into the ring cavity, and a Faraday rotator and a phase compensator configured to suppress a birefringent background as the first and second laser beams pass through the ring cavity, wherein the plurality of mirrors, Faraday rotator, and phase compensator are configured such that light from the first and second laser beams passes through a chiral material located within the cavity a sufficient number of times for a measurement of optical rotary dispersion (ORD) and circular dichroism (CD) of light transmitted through the chiral material to be obtained. Particular implementations include monolithic ring cavities or microresonators or use of intra-cavity gain media.

公开(公告)号：US20170156646A1

公开(公告)日：2017-06-08

申请号：US15239309

申请日：2016-08-17

Applicant: Zyomed Corp.

Inventor： Sandeep Gulati ,  Timothy L. Ruchti ,  William Van Antwerp ,  John L. Smith

IPC: A61B5/145 ,  A61B5/1455 ,  G01N33/49 ,  G01N21/49 ,  G01N21/359 ,  G01N33/483

CPC classification number: A61B5/14532 ,  A61B5/0075 ,  A61B5/024 ,  A61B5/02416 ,  A61B5/02433 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/7235 ,  A61B5/7253 ,  A61B5/7264 ,  A61B5/7267 ,  A61B2560/0223 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/4795 ,  G01N21/49 ,  G01N33/4833 ,  G01N33/49 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/067 ,  G01N2201/12 ,  G01N2201/129

Abstract: In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature. The conditioned features are computationally collided with one or more Zyotons that are co-dependent with the conditioned features. One or more collisions amplify a property of the analyte e.g., energy absorbed by glucose in tissue from radiation directed to the skin. A gradient of several values of the amplified property, each value corresponding to a particular radiation pattern according to a spectroscopic tomographic sequence, is used to select a suitable projector curve, with which a representative amplified value is projected to an accurate estimate of the concentration of glucose or the other analytes, without needing personalized calibration.

公开(公告)号：US20170115207A1

公开(公告)日：2017-04-27

申请号：US15400554

申请日：2017-01-06

Applicant: Honeywell International Inc.

Inventor： Wei Yang ,  Teresa M. Marta ,  Martin Willett ,  Rodney R. Watts

IPC: G01N21/17 ,  G01N33/00 ,  G01N21/61

CPC classification number: G01N21/1702 ,  G01J5/02 ,  G01J5/42 ,  G01N21/61 ,  G01N33/0027 ,  G01N2021/1704 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/12

Abstract: Gas detector devices, systems, and methods using a Golay cell are described herein. One device includes a microphone having a front surface with an sound collecting aperture for receiving sound, a substrate, a gas cavity formed in the substrate such that the gas cavity is in gas communication with the sound collecting aperture and the front surface forms a side surface of the gas cavity, and a window abutting the substrate to form a side surface of the gas cavity.

公开(公告)号：US09581842B2

公开(公告)日：2017-02-28

申请号：US14247873

申请日：2014-04-08

Applicant: SAMSUNG DISPLAY CO., LTD.

Inventor： Suk Choi ,  Sung-Mo Gu ,  Youngjin Noh ,  Youngwon Kim ,  Changhyun Ryu ,  Chi Youn Chung ,  Seunghee Lee ,  Young Eun Choi

IPC: G02F1/13 ,  G01N21/88 ,  G02F1/1337 ,  G01N21/95

CPC classification number: G02F1/1309 ,  G01N21/8806 ,  G01N2021/8848 ,  G01N2021/9513 ,  G01N2201/067 ,  G02F1/1303 ,  G02F2001/133773

Abstract: An inspection apparatus for detecting a defect of a substrate is provided. The inspection apparatus includes a liquid crystal modulator, a light emitting unit, a beam splitter, and a measurement unit. The liquid crystal modulator includes a reflection layer, a liquid crystal layer, an electrode, and a polarizer. The reflection layer reflects a light. The sensor layer includes a hybrid aligned nematic liquid crystal. The electrode is provided on the liquid crystal layer. The polarizer is provided on the electrode.

Abstract translation: 提供了用于检测基板的缺陷的检查装置。 检查装置包括液晶调制器，发光单元，分束器和测量单元。 液晶调制器包括反射层，液晶层，电极和偏振器。 反射层反射光。 传感器层包括混合排列向列型液晶。 电极设置在液晶层上。 偏振器设置在电极上。

公开(公告)号：US20170052116A1

公开(公告)日：2017-02-23

申请号：US15118981

申请日：2015-02-18

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Timothy Steimle

IPC: G01N21/64

CPC classification number: G01N21/6402 ,  G01N21/645 ,  G01N21/6486 ,  G01N2201/06113 ,  G01N2201/067

Abstract: Laser-induced fluorescence based optical system and method configured to precisely quantify the relative abundances of calcium (Ca) isotopes in a sample. Optionally, a diode laser is used as a laser source, with its output frequency shifted by two electro-optical modulators to optically excite fluorescence in the calcium-containing sample. The amounts of fluorescence emitted by the various isotopes are measured and compared.

Abstract translation: 激光诱导的基于荧光的光学系统和方法被配置为精确量化样品中钙（Ca）同位素的相对丰度。 可选地，使用二极管激光器作为激光源，其输出频率由两个电光调制器偏移以光学激发含钙样品中的荧光。 测量和比较各种同位素发射的荧光量。

公开(公告)号：US20170038294A1

公开(公告)日：2017-02-09

申请号：US14821539

申请日：2015-08-07

Applicant: Abhijeet Vikram Kshirsagar ,  Chinmaya Rajiv Dandekar ,  Sagar Shivajirao Chavan

Inventor： Abhijeet Vikram Kshirsagar ,  Chinmaya Rajiv Dandekar ,  Sagar Shivajirao Chavan

IPC: G01N21/17

CPC classification number: G01N21/1702 ,  G01N29/2418 ,  G01N29/2425 ,  G01N29/42 ,  G01N2021/1704 ,  G01N2201/067 ,  G01N2291/0215 ,  G01N2291/0217 ,  G01N2291/0427

Abstract: A cap for a gas sensor module is described herein. The cap can include at least one wall forming a cavity having a first portion and a second portion. The cap can also include an inlet tube coupling feature disposed in the at least one wall, where the first location is adjacent to the first portion of the cavity. The cap can further include an outlet tube coupling feature disposed in the at least one wall, where the second location is adjacent to the second portion of the cavity. The cap can also include a distribution channel coupling feature disposed in the at least one wall, where the third location is adjacent to the first portion of the cavity. The cap can further include a receiving channel coupling feature disposed in the at least one wall, where the fourth location is adjacent to the second portion of the cavity.

Abstract translation: 本文描述了用于气体传感器模块的盖。 盖可以包括形成具有第一部分和第二部分的空腔的至少一个壁。 盖还可以包括设置在至少一个壁中的入口管联接特征，其中第一位置与空腔的第一部分相邻。 帽可进一步包括设置在至少一个壁中的出口管连接件，其中第二位置与腔的第二部分相邻。 帽还可以包括设置在至少一个壁中的分配通道联接特征，其中第三位置与空腔的第一部分相邻。 帽可以进一步包括设置在至少一个壁中的接收通道联接特征，其中第四位置邻近空腔的第二部分。