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公开(公告)号：US20200054520A1
公开(公告)日：2020-02-20
申请号：US16348795
申请日：2017-11-10
Applicant: The Regents of the University of California
Inventor： Michael Austin Johnson , Jason Adams , Jean-Pierre Delplanque , Justin Koos , Gregory Rehm
Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.
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公开(公告)号：US20150013439A1
公开(公告)日：2015-01-15
申请号：US14372438
申请日：2013-01-25
Applicant: The Regents of the University of California
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
CPC classification number: G01N33/497 , A61B5/083 , A61B5/4845 , A61B10/0045 , G01N1/2202 , G01N1/4022 , G01N21/03 , G01N2001/002 , G01N2001/2282 , G01N2001/4033 , G01N2021/035
Abstract: A micro-analyzer is described. This micro-analyzer includes an outer surface region on a sampler surface that receives liquid droplets, and aggregates and moves the droplets radially toward an inner surface region on the sampler surface that receives the droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient. After the droplets are aggregated, an analysis mechanism in an area within the inner surface region performs analysis on the aggregated droplets.
Abstract translation: 描述微量分析仪。 该微量分析仪包括采样器表面上的接收液滴的外表面区域，并且聚集并将液滴径向移动到接收液滴的采样器表面上的内表面区域。 例如，外表面区域可以包括一组微图案化的同心环，每个环包括一组径向取向的壁 - 槽对。 此外，采样器表面可沿着朝向采样器表面的中心的径向方向越来越少的疏水性，从而产生轴对称的润湿性梯度。 在液滴聚集之后，内表面区域内的分析机构对聚集的液滴进行分析。
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公开(公告)号：US20240082104A1
公开(公告)日：2024-03-14
申请号：US18388711
申请日：2023-11-10
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Michael Austin Johnson , Jason Adams , Jean-Pierre Delplanque , Justin Koos , Gregory Rehm
CPC classification number: A61H31/00 , A61B5/0022 , A61B5/7203 , A61B5/7264 , A61B5/7282 , A61B5/7405 , A61B5/742 , A61H2201/5023 , A61H2201/5087
Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.
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4.发明授权公开(公告)号：US11813050B2
公开(公告)日：2023-11-14
申请号：US16347560
申请日：2017-11-22
Applicant: The Regents of the University of California
Inventor： Cristina E. Davis , Konstantin O. Zamuruyev , Michael Schivo , Nicholas J. Kenyon , Jean-Pierre Delplanque , Alexander A. Aksenov
CPC classification number: A61B5/082 , A61B5/097 , A61M16/0808 , G01N15/0255 , G01N33/497 , A61M15/00 , G01N2015/0288
Abstract: A selective-sorting system for aerosol droplets in human breath includes a mouthpiece to receive a flow of human breath, and a flow path coupled to the mouthpiece. This flow path includes one or more bends that cause the flow of human breath to change direction, which causes aerosol droplets in the flow having different mass-sizes to change direction at different rates. Moreover, the flow path is shaped so that droplets that change direction at different rates are directed to different destinations. The system also includes a collection path, which is coupled to the flow path so that aerosol droplets meeting a specific mass-size criterion are directed into the collection path. A condenser tube is located in the collection path, wherein the condenser tube includes a cooling mechanism that cools the condenser tube to facilitate condensing aerosol droplets to sides of the condenser tube for subsequent collection.
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公开(公告)号：US20230138861A1
公开(公告)日：2023-05-04
申请号：US17898182
申请日：2022-08-29
Applicant: The Regents of the University of California
Inventor： Michael Austin Johnson , Jason Adams , Jean-Pierre Delplanque , Justin Koos , Gregory Rehm
Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.
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Patent Agency Ranking
公开(公告)号：US11464703B2
公开(公告)日：2022-10-11
申请号：US16348795
申请日：2017-11-10
Applicant: The Regents of the University of California
Inventor： Michael Austin Johnson , Jason Adams , Jean-Pierre Delplanque , Justin Koos , Gregory Rehm
Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.
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公开(公告)号：US09398881B2
公开(公告)日：2016-07-26
申请号：US14372438
申请日：2013-01-25
Applicant: The Regents of the University of California
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
CPC classification number: G01N33/497 , A61B5/083 , A61B5/4845 , A61B10/0045 , G01N1/2202 , G01N1/4022 , G01N21/03 , G01N2001/002 , G01N2001/2282 , G01N2001/4033 , G01N2021/035
Abstract: A micro-analyzer is described. This micro-analyzer includes an outer surface region on a sampler surface that receives liquid droplets, and aggregates and moves the droplets radially toward an inner surface region on the sampler surface that receives the droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient. After the droplets are aggregated, an analysis mechanism in an area within the inner surface region performs analysis on the aggregated droplets.
Abstract translation: 描述微量分析仪。 该微量分析仪包括采样器表面上的接收液滴的外表面区域，并且聚集并且将液滴径向移动到接收液滴的采样器表面上的内表面区域。 例如，外表面区域可以包括一组微图案化的同心环，每个环包括一组径向取向的壁 - 槽对。 此外，采样器表面可沿着朝向采样器表面的中心的径向方向越来越少的疏水性，从而产生轴对称的润湿性梯度。 在液滴聚集之后，内表面区域内的分析机构对聚集的液滴进行分析。
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公开(公告)号：US11839585B2
公开(公告)日：2023-12-12
申请号：US17898182
申请日：2022-08-29
Applicant: The Regents of the University of California
Inventor： Michael Austin Johnson , Jason Adams , Jean-Pierre Delplanque , Justin Koos , Gregory Rehm
CPC classification number: A61H31/00 , A61B5/0022 , A61B5/7203 , A61B5/7264 , A61B5/7282 , A61B5/742 , A61B5/7405 , A61H2201/5023 , A61H2201/5087
Abstract: Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.
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9.发明申请公开(公告)号：US20190274584A1
公开(公告)日：2019-09-12
申请号：US16347560
申请日：2017-11-22
Applicant: The Regents of the University of California
Inventor： Cristina E. Davis , Konstantin O. Zamuruyev , Michael Schivo , Nicholas J. Kenyon , Jean-Pierre Delplanque , Alexander A. Aksenov
IPC: A61B5/08 , A61B5/097 , G01N15/02 , G01N33/497
Abstract: A selective-sorting system for aerosol droplets in human breath includes a mouthpiece to receive a flow of human breath, and a flow path coupled to the mouthpiece. This flow path includes one or more bends that cause the flow of human breath to change direction, which causes aerosol droplets in the flow having different mass-sizes to change direction at different rates. Moreover, the flow path is shaped so that droplets that change direction at different rates are directed to different destinations. The system also includes a collection path, which is coupled to the flow path so that aerosol droplets meeting a specific mass-size criterion are directed into the collection path. A condenser tube is located in the collection path, wherein the condenser tube includes a cooling mechanism that cools the condenser tube to facilitate condensing aerosol droplets to sides of the condenser tube for subsequent collection.
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公开(公告)号：US10111606B2
公开(公告)日：2018-10-30
申请号：US14372436
申请日：2013-01-25
Applicant: The Regents of the University of California
Inventor： Cristina Davis , Hamzeh Bardaweel , Konstantin Zamuruyev , Jean-Pierre Delplanque , Nicholas J. Kenyon
Abstract: An integrated condenser is described. This integrated condenser includes an outer surface region on a sampler surface that facilitates condensing at least a component in a received gas-phase sample into liquid-phase droplets on the sampler surface, and aggregating and moving the condensed droplets radially toward an inner surface region on the sampler surface that receives the condensed droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient.
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