公开(公告)号：US20190299207A1

公开(公告)日：2019-10-03

申请号：US16380693

申请日：2019-04-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Luke P. Lee ,  Jun Ho Sun

IPC: B01L3/00 ,  C12Q1/686 ,  C12N5/078

Abstract: An integrated molecular diagnostics system (iMDx) for the detection of Dengue Fever at point-of-care, wherein blood plasma separation for the selective separation of the Dengue virus from the whole blood, LED-driven photothermal lysis of the Dengue virus for the RNA extraction, and LED-driven rapid optical cavity PCR for the amplification of Dengue viral RNA are integrated on-chip within a single micro-fluidic device.

公开(公告)号：US11446667B2

公开(公告)日：2022-09-20

申请号：US16380693

申请日：2019-04-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Luke P. Lee ,  Jun Ho Sun

IPC: C12Q1/68 ,  B01L3/00 ,  C12N5/078 ,  C12Q1/686 ,  C12Q1/6834 ,  C12Q1/70 ,  B01L7/00

Abstract: An integrated molecular diagnostics system (iMDx) for the detection of Dengue Fever at point-of-care, wherein blood plasma separation for the selective separation of the Dengue virus from the whole blood, LED-driven photothermal lysis of the Dengue virus for the RNA extraction, and LED-driven rapid optical cavity PCR for the amplification of Dengue viral RNA are integrated on-chip within a single micro-fluidic device.