公开(公告)号：US20150153558A1

公开(公告)日：2015-06-04

申请号：US14406199

申请日：2013-06-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Onur Mudanyali ,  Euan McLeod

IPC: G02B21/36 ,  G02B21/00 ,  G02B21/14

CPC classification number: G02B21/367 ,  G01B9/04 ,  G01N15/1434 ,  G01N15/1463 ,  G01N2015/1006 ,  G01N2015/144 ,  G02B3/12 ,  G02B21/0004 ,  G02B21/14 ,  G02B21/34 ,  G03H1/0443 ,  G03H1/0465 ,  G03H1/0866 ,  G03H2001/0447 ,  G03H2001/0883 ,  G03H2222/36 ,  G03H2240/56

Abstract: A method of imaging a sample includes depositing a droplet containing the sample on a substrate, the sample having a plurality of particles contained within a fluid. The substrate is then tilted to gravitationally drive the droplet to an edge of the substrate while forming a dispersed monolayer of particles having liquid lenses surrounding the particles. A plurality of lower resolution images of the particles contained on the substrate are obtained, wherein the substrate is interposed between an illumination source and an image sensor, wherein each lower resolution image is obtained at discrete spatial locations. The plurality of lower resolution images of the particles are converted into a higher resolution image. At least one of an amplitude image and a phase image of the particles contained within the sample is then reconstructed. In some embodiments, only a single lower resolution image may be sufficient.

Abstract translation: 成像样品的方法包括将含有样品的液滴沉积在基底上，样品具有包含在流体内的多个颗粒。 然后将衬底倾斜以重力地将液滴驱动到衬底的边缘，同时形成具有围绕颗粒的液体透镜的分散的单层颗粒。 获得包含在基板上的颗粒的多个较低分辨率图像，其中基板被插入在照明源和图像传感器之间，其中在离散的空间位置处获得每个下分辨率图像。 颗粒的多个较低分辨率图像被转换成更高分辨率的图像。 然后重建样品中包含的颗粒的幅度图像和相位图像中的至少一个。 在一些实施例中，仅一个较低分辨率的图像可能是足够的。

公开(公告)号：US10663466B2

公开(公告)日：2020-05-26

申请号：US14530517

申请日：2014-10-31

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Onur Mudanyali ,  Stoyan Dimitrov ,  Uzair Sikora ,  Swati Padmanabhan ,  Isa Navrus

IPC: G01N33/569 ,  G06F16/245 ,  G01N21/84 ,  G01N21/64 ,  G16H15/00 ,  G06K7/10 ,  G01N21/01 ,  G01N21/77 ,  G01N21/82 ,  G01N33/543

Abstract: A portable rapid diagnostic test reader system includes a mobile phone having a camera and one or more processors contained within the mobile phone and a modular housing configured to mount to the mobile phone. The modular housing including a receptacle configured to receive a sample tray holding a rapid diagnostic test. At least one illumination source is disposed in the modular housing and located on one side of the rapid diagnostic test. An optical demagnifier is disposed in the modular housing interposed between the rapid diagnostic test and the mobile phone camera.

公开(公告)号：US20150111201A1

公开(公告)日：2015-04-23

申请号：US14530517

申请日：2014-10-31

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Onur Mudanyali ,  Stoyan Dimitrov ,  Uzair Sikora ,  Swati Padmanabhan ,  Isa Navrus

IPC: G06F19/00 ,  G01N21/01 ,  G06F17/30 ,  G01N33/569

CPC classification number: G01N33/56905 ,  B01L2300/0825 ,  G01N21/01 ,  G01N21/645 ,  G01N21/8483 ,  G01N33/543 ,  G01N33/5695 ,  G01N33/56988 ,  G01N2021/0118 ,  G01N2021/7786 ,  G01N2021/825 ,  G01N2021/8488 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/0634 ,  G06F16/245 ,  G06K7/10732 ,  G06K7/10831 ,  G16H15/00 ,  Y02A90/22 ,  Y02A90/24 ,  Y02A90/26

Abstract: A portable rapid diagnostic test reader system includes a mobile phone having a camera and one or more processors contained within the mobile phone and a modular housing configured to mount to the mobile phone. The modular housing including a receptacle configured to receive a sample tray holding a rapid diagnostic test. At least one illumination source is disposed in the modular housing and located on one side of the rapid diagnostic test. An optical demagnifier is disposed in the modular housing interposed between the rapid diagnostic test and the mobile phone camera.

Abstract translation: 便携式快速诊断测试读取器系统包括具有照相机的移动电话和包含在移动电话内的一个或多个处理器以及被配置为安装到移动电话的模块化外壳。 模块化壳体包括被配置成容纳保持快速诊断测试的样品托盘的插座。 至少一个照明源设置在模块化壳体中并且位于快速诊断测试的一侧。 光学消音器设置在插入快速诊断测试和移动电话摄像机之间的模块化壳体中。