公开(公告)号：US11364042B2

公开(公告)日：2022-06-21

申请号：US16293394

申请日：2019-03-05

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Adam D. Maxwell ,  Zhen Xu ,  Hitinder S. Gurm ,  Charles A. Cain

IPC: A61B17/22 ,  A61B17/225 ,  A61M37/00 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B90/00

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

公开(公告)号：US10293187B2

公开(公告)日：2019-05-21

申请号：US14323693

申请日：2014-07-03

Applicant: Histosonics, Inc. ,  The Regents of the University of Michigan

Inventor： Jonathan M. Cannata ,  Timothy L. Hall ,  Adam D. Maxwell ,  Dejan Teofilovic

IPC: A61N7/00 ,  A61B17/00 ,  A61B17/22 ,  A61B17/225

Abstract: Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.

公开(公告)号：US09867999B2

公开(公告)日：2018-01-16

申请号：US15309394

申请日：2015-05-15

Applicant: University of Washington ,  The Regents of the University of Michigan

Inventor： Adam D. Maxwell ,  Bryan Cunitz ,  Michael R. Bailey ,  Vera Khokhlova ,  Timothy L. Hall

IPC: A61N7/00 ,  A61B17/22 ,  B06B1/02 ,  A61N7/02 ,  G01S7/52

CPC classification number: A61N7/00 ,  A61B17/22004 ,  A61N7/02 ,  A61N2007/0073 ,  A61N2007/0078 ,  A61N2007/0095 ,  B06B1/0215 ,  B06B2201/55 ,  G01S7/5202

Abstract: Embodiments of the invention include improved radiofrequency (RF) pulse amplifier systems that incorporate an energy array comprising multiple capacitors connected in parallel. The energy array extends the maximum length of pulses and the maximum achievable peak power output of the amplifier when compared to similar systems. Embodiments also include systems comprising the amplifier configured to drive a load, wherein the load may include one or more ultrasound (e.g., piezoelectric) transducers Related methods of using the amplifier are also provided.

公开(公告)号：US11701134B2

公开(公告)日：2023-07-18

申请号：US17838085

申请日：2022-06-10

Applicant: The Regents of the University of Michigan

Inventor： Adam D. Maxwell ,  Zhen Xu ,  Hitinder S. Gurm ,  Charles A. Cain

IPC: A61B17/22 ,  A61B17/225 ,  A61M37/00 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B90/00

CPC classification number: A61B17/22004 ,  A61B17/2258 ,  A61M37/0092 ,  A61B5/055 ,  A61B5/0536 ,  A61B8/00 ,  A61B8/08 ,  A61B8/485 ,  A61B2017/00154 ,  A61B2017/00172 ,  A61B2017/00778 ,  A61B2017/22001 ,  A61B2017/22008 ,  A61B2017/22088 ,  A61B2017/22089 ,  A61B2090/378

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

公开(公告)号：US11058399B2

公开(公告)日：2021-07-13

申请号：US15713441

申请日：2017-09-22

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zhen Xu ,  Ryan M. Miller ,  Adam D. Maxwell ,  Charles A. Cain

IPC: A61B8/08 ,  A61B17/22 ,  A61B17/225 ,  A61B8/00 ,  A61B5/00 ,  G01S15/89

Abstract: A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.

公开(公告)号：US12150661B2

公开(公告)日：2024-11-26

申请号：US18329459

申请日：2023-06-05

Applicant: The Regents of the University of Michigan

Inventor： Adam D. Maxwell ,  Zhen Xu ,  Hitinder S. Gurm ,  Charles A. Cain

IPC: A61B17/22 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B17/225 ,  A61B90/00 ,  A61M37/00

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”