公开(公告)号：US12150661B2

公开(公告)日：2024-11-26

申请号：US18329459

申请日：2023-06-05

Applicant: The Regents of the University of Michigan

Inventor： Adam D. Maxwell ,  Zhen Xu ,  Hitinder S. Gurm ,  Charles A. Cain

IPC: A61B17/22 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B17/225 ,  A61B90/00 ,  A61M37/00

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

公开(公告)号：US11819712B2

公开(公告)日：2023-11-21

申请号：US17008369

申请日：2020-08-31

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Charles A. Cain ,  Adam Maxwell ,  Zhen Xu ,  Kuang-Wei Lin

IPC: A61N7/00 ,  A61B17/32

CPC classification number: A61N7/00 ,  A61B2017/320069 ,  A61N2007/003 ,  A61N2007/0039 ,  A61N2007/0065

Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P−) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.

公开(公告)号：US11364042B2

公开(公告)日：2022-06-21

申请号：US16293394

申请日：2019-03-05

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Adam D. Maxwell ,  Zhen Xu ,  Hitinder S. Gurm ,  Charles A. Cain

IPC: A61B17/22 ,  A61B17/225 ,  A61M37/00 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B90/00

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

公开(公告)号：US11135454B2

公开(公告)日：2021-10-05

申请号：US15737761

申请日：2016-06-23

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zhen Xu ,  Jonathan Sukovich ,  Aditya S. Pandey ,  Charles A. Cain ,  Hitinder S. Gurm

IPC: A61N7/02 ,  A61N7/00

Abstract: A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

公开(公告)号：US11701134B2

公开(公告)日：2023-07-18

申请号：US17838085

申请日：2022-06-10

Applicant: The Regents of the University of Michigan

Inventor： Adam D. Maxwell ,  Zhen Xu ,  Hitinder S. Gurm ,  Charles A. Cain

IPC: A61B17/22 ,  A61B17/225 ,  A61M37/00 ,  A61B5/0536 ,  A61B5/055 ,  A61B8/00 ,  A61B8/08 ,  A61B17/00 ,  A61B90/00

CPC classification number: A61B17/22004 ,  A61B17/2258 ,  A61M37/0092 ,  A61B5/055 ,  A61B5/0536 ,  A61B8/00 ,  A61B8/08 ,  A61B8/485 ,  A61B2017/00154 ,  A61B2017/00172 ,  A61B2017/00778 ,  A61B2017/22001 ,  A61B2017/22008 ,  A61B2017/22088 ,  A61B2017/22089 ,  A61B2090/378

Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

公开(公告)号：US11058399B2

公开(公告)日：2021-07-13

申请号：US15713441

申请日：2017-09-22

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zhen Xu ,  Ryan M. Miller ,  Adam D. Maxwell ,  Charles A. Cain

IPC: A61B8/08 ,  A61B17/22 ,  A61B17/225 ,  A61B8/00 ,  A61B5/00 ,  G01S15/89

Abstract: A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.

公开(公告)号：US09636133B2

公开(公告)日：2017-05-02

申请号：US13874083

申请日：2013-04-30

Applicant: The Regents of the University of Michigan

Inventor： Timothy L. Hall ,  Adam Maxwell ,  Charles A. Cain ,  Yohan Kim ,  Zhen Xu

IPC: A61B17/225 ,  H01L41/053 ,  A61B17/32 ,  H01L41/04 ,  H01L41/23 ,  H01L41/25 ,  A61N7/02 ,  G10K11/00 ,  G01N29/22 ,  G01N29/24 ,  A61B17/00 ,  A61N7/00

CPC classification number: A61N7/02 ,  A61B17/225 ,  A61B17/320068 ,  A61B2017/00526 ,  A61N2007/0039 ,  A61N2007/006 ,  A61N2007/0065 ,  A61N2007/0091 ,  A61N2007/0095 ,  B06B1/0607 ,  B33Y10/00 ,  B33Y80/00 ,  G01N29/223 ,  G01N29/225 ,  G01N29/226 ,  G01N29/2437 ,  G01N29/245 ,  G10K11/004 ,  H01L41/04 ,  H01L41/053 ,  H01L41/1876 ,  H01L41/23 ,  H01L41/25 ,  Y10T29/42 ,  Y10T29/49005 ,  Y10T29/49007

Abstract: An ultrasound therapy system is provided that can include any number of features. In some embodiments, the custom transducer housings can be manufactured using a rapid-prototyping method to arrange a plurality of single-element, substantially flat transducers to share a common focal point. The rapid-prototyping method can include, for example, fused-deposition modeling, 3D printing, and stereolithography. In some embodiments, the therapy system can include a plurality of transducer modules insertable into the openings of the transducer housing. Methods of manufacture are also described, including designing a transducer housing shell to a desired geometry and a plurality of acoustic focusing lenses integral to the transducer housing shell in a 3D computer aided design software, and constructing the transducer housing shell and the plurality of acoustic focusing lenses integral to the transducer housing shell using a rapid-prototyping method.

公开(公告)号：US12220602B2

公开(公告)日：2025-02-11

申请号：US17407780

申请日：2021-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zhen Xu ,  Jonathan Sukovich ,  Aditya S. Pandey ,  Charles A. Cain ,  Hitinder S. Gurm

IPC: A61N7/00 ,  A61N7/02

Abstract: A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

公开(公告)号：US20250017608A1

公开(公告)日：2025-01-16

申请号：US18715639

申请日：2022-12-01

Applicant: NORTH CAROLINA STATE UNIVERSITY ,  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Paul Alexander Dayton ,  Jinwook KIM ,  Xiaoning Jiang ,  Bohua Zhang ,  Huaiyu Wu ,  Zhen Xu

IPC: A61B17/22

Abstract: A method for disrupting a blood clot with ultrasound and at least one cavitation enhancing agent includes administering at least one cavitation enhancing agent into a blood vessel of a subject. The method further includes monitoring the at least one cavitation enhancing agent to determine when at least a portion of the at least one cavitation enhancing agent has reached a blood clot. The method further includes controlling application of ultrasound energy to the at least one cavitation enhancing agent within the blood vessel of the subject such that, during a first time period, cavitation-enhancing ultrasound energy is not applied to the at least one cavitation enhancing agent within the blood vessel and, during a second time period after the first time period, cavitation enhancing ultrasound energy is applied to the at least one cavitation enhancing agent within the blood vessel.

公开(公告)号：US11813485B2

公开(公告)日：2023-11-14

申请号：US17161498

申请日：2021-01-28

Applicant: The Regents of the University of Michigan ,  The United States Government as represented by the Department of Veterans Affairs

Inventor： Zhen Xu ,  Clifford Suhyun Cho

IPC: A61N7/00 ,  A61K39/00 ,  A61B10/00

CPC classification number: A61N7/00 ,  A61K39/0011 ,  A61B10/0045

Abstract: Systems and methods for histotripsy and immunotherapy are provided. In some embodiments, histotripsy can be applied to a target tissue volume to lyse and solubilize the target tissue volume to release tumor antigens. In some embodiments, an immune response of the treatment can be evaluated. In other embodiments, an immune therapy can be applied after applying the histotripsy. In one embodiment, the lysed and solubilized cells can be extracted from the tissue. The extracted cells can be used to create immune therapies, including vaccines.