公开(公告)号：US11135454B2

公开(公告)日：2021-10-05

申请号：US15737761

申请日：2016-06-23

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zhen Xu ,  Jonathan Sukovich ,  Aditya S. Pandey ,  Charles A. Cain ,  Hitinder S. Gurm

IPC: A61N7/02 ,  A61N7/00

Abstract: A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

公开(公告)号：US12220602B2

公开(公告)日：2025-02-11

申请号：US17407780

申请日：2021-08-20

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Zhen Xu ,  Jonathan Sukovich ,  Aditya S. Pandey ,  Charles A. Cain ,  Hitinder S. Gurm

IPC: A61N7/00 ,  A61N7/02

Abstract: A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.