公开(公告)号：US20160377637A1

公开(公告)日：2016-12-29

申请号：US15116533

申请日：2015-02-05

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Francis W.l. Esmonde-White ,  Karen A. Esmonde-White ,  Michael D. Morris ,  Blake J. Roessler

IPC: G01N33/84 ,  G01N21/65 ,  C12Q1/04

CPC classification number: G01N33/84 ,  C12N5/0654 ,  C12Q1/04 ,  G01N21/65 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2800/10

Abstract: Example methods and apparatus are disclosed for diagnosing or assisting a diagnosis of a bone tissue condition. A specimen associated with bone tissue suspected of being infected is irradiated using a monochromatic light source. The specimen may be irradiated in vivo or ex vivo, and/or within a growth medium. Light scattered during the irradiation is gathered and its Raman spectral content is determined to detect one or more pathological calcium phosphate minerals, such as brushite and uncarbonated apatite, resulting from a conversion of carbonated-apatite in the presence of bacteria.

Abstract translation: 公开了用于诊断或辅助骨组织状况诊断的示例性方法和装置。 使用单色光源照射与疑似被感染的骨组织相关的标本。 样品可以在体内或体外照射和/或在生长培养基内照射。 在照射期间散射的光被聚集，并且其拉曼光谱含量被确定以检测在细菌存在下由碳酸化磷灰石转化而产生的一种或多种病理性磷酸钙矿物质，例如透钙石和非碳酸化磷灰石。

公开(公告)号：US12220244B2

公开(公告)日：2025-02-11

申请号：US16470678

申请日：2017-12-21

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Benjamin Levi ,  Omer Berenfeld ,  Michael D. Morris

IPC: A61B5/00 ,  A61B5/107

Abstract: A short wave infrared (SWIR) imaging system and method of using the same is provided for assessing a tissue damage depth and/or readiness for reconstruction and/or debridement. The SWIR imaging system includes a light source for illuminating the wound or burn, an image light-registering camera system having at least one narrow-band SWIR filter to image the wound or burn and output imaging information, and a detection system for receiving the imaging information and processing the imaging information to determine a tissue damage depth and/or readiness for reconstruction and/or debridement assessment.