公开(公告)号：US11590234B2

公开(公告)日：2023-02-28

申请号：US15720542

申请日：2017-09-29

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Peter X. Ma ,  Xiaojin Zhang

IPC: A61K47/00 ,  A61K47/50 ,  A61K47/59 ,  C08G83/00 ,  C08G73/02 ,  C08F210/02 ,  C08G63/66 ,  A61K47/69 ,  A61K47/60 ,  A61L27/18 ,  A61L27/26 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C08G81/00 ,  C12N15/113

Abstract: A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems.

公开(公告)号：US20230120244A1

公开(公告)日：2023-04-20

申请号：US18076030

申请日：2022-12-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Peter X. Ma ,  Xiaojin Zhang

IPC: A61K47/59 ,  C08G73/02 ,  A61L27/18 ,  A61L27/58 ,  C08G83/00 ,  C12N15/113 ,  C08G81/00 ,  A61L27/56 ,  A61L27/54 ,  A61K47/69 ,  A61L27/44 ,  A61K47/50 ,  A61K47/60 ,  A61L27/52 ,  C08G63/66 ,  C08F210/02 ,  A61L27/26

Abstract: A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems.

公开(公告)号：US20180021441A1

公开(公告)日：2018-01-25

申请号：US15720542

申请日：2017-09-29

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Peter X. Ma ,  Xiaojin Zhang

IPC: A61K47/59 ,  C08G81/00 ,  C08G63/66 ,  C08G73/02 ,  A61K47/60 ,  A61K47/69 ,  A61L27/58 ,  A61L27/52 ,  A61L27/54 ,  A61L27/44 ,  A61L27/18 ,  A61L27/26 ,  A61L27/56 ,  C12N15/113 ,  C08G83/00

CPC classification number: A61K47/593 ,  A61K47/50 ,  A61K47/60 ,  A61K47/6937 ,  A61L27/18 ,  A61L27/26 ,  A61L27/44 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/258 ,  A61L2300/604 ,  A61L2430/02 ,  C08F210/02 ,  C08G63/66 ,  C08G73/0206 ,  C08G73/024 ,  C08G81/00 ,  C08G83/00 ,  C08G83/005 ,  C08G2210/00 ,  C08G2230/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/351 ,  C12N2310/51 ,  C12N2310/52

Abstract: A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems.