公开(公告)号：US20180243469A1

公开(公告)日：2018-08-30

申请号：US15753556

申请日：2016-08-31

Applicant: THE UNIVERSITY OF SYDNEY

Inventor： Ali Fathi ,  Fariba Dehghani ,  Anthony Weiss ,  Suzannne Mithieux

IPC: A61L27/16 ,  C08F220/28 ,  C08L33/26 ,  C08L89/00 ,  A61K9/00 ,  A61K31/787 ,  A61L27/54 ,  A61L27/52 ,  A61K38/39 ,  A61L27/24 ,  A61L27/58 ,  A61L27/22 ,  A61K38/17 ,  A61F2/28

CPC classification number: A61L27/16 ,  A61F2/28 ,  A61F2002/2817 ,  A61K9/0019 ,  A61K31/787 ,  A61K38/1709 ,  A61K38/39 ,  A61K47/32 ,  A61K47/42 ,  A61L27/227 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/02 ,  C08F220/28 ,  C08F2220/285 ,  C08L33/14 ,  C08L33/26 ,  C08L89/00 ,  C08L2201/06 ,  C08L2201/54 ,  C08L2203/02

Abstract: Disclosed herein are biocompatible materials useful for tissue regeneration and repair, wherein the bioactive polymer may be in the form of a hydrogel, for example a thermoresponsive hydrogel. This bioactive polymer and a resulting hydrogel, may be used for the regeneration of bone tissue. Accordingly, also disclosed herein are methods of treating a bone defect in a mammal, the methods comprising administering a therapeutically effective amount of a hydrogel formed by the bioactive polymer to the mammal to treat the bone defect.

公开(公告)号：US09546235B2

公开(公告)日：2017-01-17

申请号：US14366663

申请日：2012-12-19

Applicant: The University of Sydney

Inventor： Fariba Dehghani ,  Anthony Steven Weiss ,  Hua Wei ,  Suzanne Marie Mithieux ,  Ali Fathi

IPC: C08F220/54 ,  A61K47/48 ,  C08F220/28 ,  C08F220/36

CPC classification number: C08F220/54 ,  A61K47/605 ,  A61K47/6903 ,  C08F220/28 ,  C08F220/36 ,  C08F2220/283 ,  C08F2220/286

Abstract: The present invention relates to polymers, especially polymers useful as hydrogels, and to use of hydrogels for repair or restoration of tissue. In particular, the polymers and hydrogels of the present invention can be used for the repair or restoration of cartilage, especially articular cartilage. The polymers comprise at least a monomer for binding water, a monomer for imparting mechanical properties and a monomer for binding to an extracellular protein. The hydrogels comprise a polymer comprising at least a monomer for binding water and a monomer for binding to an extracellular protein. Crosslinking polymers by binding of said extra-cellular matrix protein forms hydrogels.

Abstract translation: 本发明涉及聚合物，特别是可用作水凝胶的聚合物，以及使用水凝胶来修复或恢复组织。 特别地，本发明的聚合物和水凝胶可用于软骨的修复或恢复，特别是关节软骨。 聚合物至少包含用于结合水的单体，用于赋予机械性能的单体和用于结合细胞外蛋白质的单体。 水凝胶包含至少包含用于结合水的单体和用于结合细胞外蛋白的单体的聚合物。 通过结合所述细胞外基质蛋白的交联聚合物形成水凝胶。

公开(公告)号：US20140357823A1

公开(公告)日：2014-12-04

申请号：US14366663

申请日：2012-12-19

Applicant: The University of Sydney

Inventor： Fariba Dehghani ,  Anthony Steven Weiss ,  Hua Wei ,  Suzanne Marie Mithieux ,  Ali Fathi

IPC: C08F220/54

CPC classification number: C08F220/54 ,  A61K47/605 ,  A61K47/6903 ,  C08F220/28 ,  C08F220/36 ,  C08F2220/283 ,  C08F2220/286

Abstract: The present invention relates to polymers, especially polymers useful as hydrogels, and to use of hydrogels for repair or restoration of tissue. In particular, the polymers and hydrogels of the present invention can be used for the repair or restoration of cartilage, especially articular cartilage. The polymers comprise at least a monomer for binding water, a monomer for imparting mechanical properties and a monomer for binding to an extracellular protein. The hydrogels comprise a polymer comprising at least a monomer for binding water and a monomer for binding to an extracellular protein. Crosslinking polymers by binding of said extra-cellular matrix protein forms hydrogels.

Abstract translation: 本发明涉及聚合物，特别是可用作水凝胶的聚合物，以及使用水凝胶来修复或恢复组织。 特别地，本发明的聚合物和水凝胶可用于软骨的修复或恢复，特别是关节软骨。 聚合物至少包含用于结合水的单体，用于赋予机械性能的单体和用于结合细胞外蛋白质的单体。 水凝胶包含至少包含用于结合水的单体和用于结合细胞外蛋白的单体的聚合物。 通过结合所述细胞外基质蛋白的交联聚合物形成水凝胶。