公开(公告)号：US20210040218A1

公开(公告)日：2021-02-11

申请号：US16991528

申请日：2020-08-12

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro IWAKURA ,  Noriyuki Fujikado ,  Guangyu Ma

IPC: C07K16/28 ,  A61K31/737 ,  G01N33/50

Abstract: An object of the present invention is to find a ligand for a DCIR and to search for an agonist and an antagonist for the DCIR.
Specifically, disclosed are: a dendritic cell immunoreceptor agonist containing keratan sulfate-II (KS-II) as an active ingredient; an antibody against dendritic cell immunoreceptor, having a keratan sulfate-II-like dendritic cell immunoreceptor agonism; and an antibody against a dendritic cell immunoreceptor, having a keratan sulfate-II inhibitory dendritic cell immunoreceptor antagonism.