公开(公告)号：US12042492B2

公开(公告)日：2024-07-23

申请号：US17496921

申请日：2021-10-08

Applicant: Texas Tech University System

Inventor： P. Hemachandra Reddy ,  Jangampalli Adi Pradeepkiran

IPC: A61K31/473 ,  A61K31/222 ,  A61K31/395 ,  A61K31/4015 ,  A61K31/4196 ,  G16B15/30

CPC classification number: A61K31/473 ,  A61K31/222 ,  A61K31/395 ,  A61K31/4015 ,  A61K31/4196 ,  G16B15/30

Abstract: The present invention includes a method of inhibiting an activity of a BACE1 protein comprising contacting the BACE1 protein with a ligand that specifically inhibits residue Asp 32 of the human BACE1 protein.