公开(公告)号：US12042492B2

公开(公告)日：2024-07-23

申请号：US17496921

申请日：2021-10-08

Applicant: Texas Tech University System

Inventor： P. Hemachandra Reddy ,  Jangampalli Adi Pradeepkiran

IPC: A61K31/473 ,  A61K31/222 ,  A61K31/395 ,  A61K31/4015 ,  A61K31/4196 ,  G16B15/30

CPC classification number: A61K31/473 ,  A61K31/222 ,  A61K31/395 ,  A61K31/4015 ,  A61K31/4196 ,  G16B15/30

Abstract: The present invention includes a method of inhibiting an activity of a BACE1 protein comprising contacting the BACE1 protein with a ligand that specifically inhibits residue Asp 32 of the human BACE1 protein.

公开(公告)号：US11591597B2

公开(公告)日：2023-02-28

申请号：US17049041

申请日：2019-04-18

Applicant: Texas Tech University System

Inventor： P. Hemachandra Reddy ,  Murali Vijayan

IPC: C12N15/113 ,  C12Q1/6883 ,  A61P9/10

Abstract: The present invention includes methods for detecting and reducing or inhibiting ischemic stroke in a mammal, the method comprising: (a) selecting microRNAs to downregulate selected from the group consisting of hsa-miR-96-5p, hsa-miR-99a-5p, hsa-miR-122-5p, hsa-miR-186-5p, hsa-miR-211-5p, hsa-mir-760, PC-3p-57664, or PC-5p-12969, (b) selecting microRNAs to upregulate selected from the group consisting of ggo-miR-139, hsa-miR-30d-5p, hsa-miR-22-3p, hsa-miR-23a-3p, mmu-miR-5124a, mmu-mir-6240-5p, PC-3p-32463, or PC-5p-211, and combinations thereof, and (c) administering an agent that: downregulates that targets in (a), upregulates the targets in (b), or both, to the subject in an amount sufficient to reduce or inhibit ischemic stroke in the mammal. The present invention also includes the detection of the markers for use with stroke patients.

公开(公告)号：US20190307749A1

公开(公告)日：2019-10-10

申请号：US16380211

申请日：2019-04-10

Applicant: Texas Tech University System

Inventor： P. Hemachandra Reddy ,  K. Chandra Sekhar

IPC: A61K31/517 ,  A61K35/12 ,  A61K9/08 ,  A61K9/00

Abstract: The present invention includes a method for preventing or treating a disease or condition with excessive fragmentation of mitochondria or mitochondrial dysfunction comprising, consisting essentially of, or consisting of: identifying a subject suspected of needing treatment for excessive fragmentation of mitochondria or mitochondrial dysfunction; and administering to the subject with an amount of a mitochondrial division inhibitor 1 sufficient to prevent or treat the excessive fragmentation of mitochondria or mitochondrial dysfunction.

公开(公告)号：US11492669B2

公开(公告)日：2022-11-08

申请号：US16630068

申请日：2018-07-12

Applicant: Texas Tech University System

Inventor： P. Hemachandra Reddy ,  Subodh Kumar

IPC: C12Q1/6883 ,  A61K31/7088

Abstract: The present invention includes a method for identifying an Alzheimer's disease (AD) patient prior to reaching clinical disease classification, comprising: obtaining a dataset associated with a blood, serum, or plasma sample from the patient, wherein the dataset comprises data representing the level of one or more microRNA biomarkers in the blood, serum, or plasma sample; assessing the dataset for a presence or an increase in an amount of miRNA-455-3p; determining the likelihood that the patient will develop AD patient prior to reaching clinical disease classification by detecting the presence or the increase in miRNA-455-3p to produce a score that is indicative of a likelihood of developing AD, wherein a higher score relative to a healthy control indicates that the patient is likely to have the prognosis for transitioning to classified AD, wherein the healthy control is derived from a non-AD patient with no clinical evidence of AD.

公开(公告)号：US20220110931A1

公开(公告)日：2022-04-14

申请号：US17496921

申请日：2021-10-08

Applicant: Texas Tech University System

Inventor： P. Hemachandra Reddy

IPC: A61K31/473 ,  A61K31/4015 ,  A61K31/222 ,  A61K31/4196 ,  A61K31/395 ,  G16B15/30

Abstract: The present invention includes a method of inhibiting an activity of a BACE1 protein comprising contacting the BACE1 protein with a ligand that specifically inhibits residue Asp 32 of the human BACE1 protein.

公开(公告)号：US20200255900A1

公开(公告)日：2020-08-13

申请号：US16865392

申请日：2020-05-03

Applicant: Texas Tech University System

Inventor： P. Hemachandra Reddy ,  Subodh Kumar

IPC: C12Q1/6883 ,  A61K31/7105 ,  C12Q1/686 ,  A61K9/51

Abstract: The present invention includes a method of protecting neuronal cells from Aβ-induced toxicities in a subject comprising: providing the subject in need of treatment for an Aβ-induced toxicity with an agent that increases the miRNA-445-3p in the subject, wherein an increase in miR-455-3p expression in the neuronal cells enhances neuronal cell survival.

公开(公告)号：US20200255899A1

公开(公告)日：2020-08-13

申请号：US16865370

申请日：2020-05-03

Applicant: Texas Tech University System

Inventor： P. Hemachandra Reddy ,  Subodh Kumar

IPC: C12Q1/6883

Abstract: The present invention includes a method of protecting neuronal cells from Aβ-induced toxicities in a subject comprising: providing the subject in need of treatment for an Aβ-induced toxicity with an agent that increases the miRNA-445-3p in the subject, wherein an increase in miR-455-3p expression in the neuronal cells enhances neuronal cell survival.