公开(公告)号：US10370416B2

公开(公告)日：2019-08-06

申请号：US15446315

申请日：2017-03-01

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo ,  Junwei Li

IPC: C07K14/005 ,  G01N33/50 ,  A61K39/07 ,  A61K39/12 ,  A61K39/00

Abstract: The present invention includes antigenic fusion proteins, nucleic acids encoding the fusion proteins and methods of making and using the same, wherein the fusion protein comprises three or more different influenza A ectodomains of Matrix Protein 2 (M2e); one or more stem regions of an influenza A hemagglutinin 2 (HA2) protein; and optionally an anthrax antigen, wherein the fusion protein is immunogenic across strains.

公开(公告)号：US20170253636A1

公开(公告)日：2017-09-07

申请号：US15446315

申请日：2017-03-01

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo ,  Junwei Li

IPC: C07K14/005 ,  G01N33/50 ,  A61K39/145

CPC classification number: C07K14/005 ,  A61K39/07 ,  A61K39/12 ,  A61K2039/543 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/40 ,  C07K2319/55 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16162 ,  G01N33/5023 ,  G01N33/5088 ,  G01N2333/11 ,  G01N2333/32

Abstract: The present invention includes antigenic fusion proteins, nucleic acids encoding the fusion proteins and methods of making and using the same, wherein the fusion protein comprises three or more different influenza A ectodomains of Matrix Protein 2 (M2e); one or more stem regions of an influenza A hemagglutinin 2 (HA2) protein; and optionally an anthrax antigen, wherein the fusion protein is immunogenic across strains.

公开(公告)号：US10286062B2

公开(公告)日：2019-05-14

申请号：US14903611

申请日：2014-07-09

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Junwei Li

IPC: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00 ,  G01N33/569 ,  A61K39/00

Abstract: The present invention includes an isolated antigen against influenza A and a method of making the same that includes an ectodomain of influenza A Matrix Protein 2 (M2e) and a stem region of an influenza A hemagglutinin 2 (HA2) protein and an adjuvant. The invention further includes formulating the antigen into an isolated immune response stimulating fusion protein and/or a vaccine.

公开(公告)号：US20170232097A1

公开(公告)日：2017-08-17

申请号：US15518781

申请日：2015-10-14

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Junwei Li

IPC: A61K39/145 ,  C12N15/113 ,  C12N15/86 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/575 ,  C12N7/00 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/141 ,  C12N2330/51 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16161 ,  C12N2760/16171

Abstract: The present invention includes a live attenuated virus and methods of making the same comprising an isolated virus comprising a viral genome that expresses one or more viral antigens; and one or more exogenous species-specific microRNAs inserted into the viral genome and expressed thereby, wherein the species-specific microRNAs are ubiquitously expressed in a viral target species cell but not in a viral propagation cell.

公开(公告)号：US20160151480A1

公开(公告)日：2016-06-02

申请号：US14903611

申请日：2014-07-09

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： Mingtao Zeng ,  Junwei Li

IPC: A61K39/145 ,  A61K39/39 ,  G01N33/569 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55544 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/70 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/55 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  G01N33/56983 ,  G01N2500/00

Abstract: The present invention includes an isolated antigen against influenza A and a method of making the same that includes an ectodomain of influenza A Matrix Protein 2 (M2e) and a stem region of an influenza A hemagglutinin 2 (HA2) protein and an adjuvant. The invention further includes formulating the antigen into an isolated immune response stimulating fusion protein and/or a vaccine.

Abstract translation: 本发明包括针对甲型流感的分离抗原及其制备方法，其包括甲型流感病毒基质蛋白2（M2e）的胞外域和甲型流感血凝素2（HA2）蛋白和佐剂的茎区。 本发明还包括将抗原配制成刺激融合蛋白和/或疫苗的分离的免疫应答。