公开(公告)号：US10479998B2

公开(公告)日：2019-11-19

申请号：US15838556

申请日：2017-12-12

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo

IPC: C07K16/28 ,  C12N15/11 ,  C12N15/113

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

公开(公告)号：US20210236622A1

公开(公告)日：2021-08-05

申请号：US17048714

申请日：2019-04-18

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Ke Wen

IPC: A61K39/145 ,  A61K39/39 ,  C12N7/00 ,  C12N15/113

Abstract: The present invention includes a live, self-attenuated therapeutic vaccine, virus and methods of making and using the same, comprising: an isolated virus comprising a viral genome that expresses one or more viral antigens; and an artificial microRNA 30 (amiR-30) expression cassette inserted into a viral neuraminidase (NA) or a viral non-structural (NS) gene segment that expresses an amiR-30 that specifically inhibits the expression of a host gene essential for influenza virus replication in host cells.

公开(公告)号：US20180112223A1

公开(公告)日：2018-04-26

申请号：US15838556

申请日：2017-12-12

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo

IPC: C12N15/113 ,  C07K16/28

CPC classification number: C12N15/1138 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/30

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

公开(公告)号：US20160145627A1

公开(公告)日：2016-05-26

申请号：US14898179

申请日：2014-06-12

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： Mingtao Zeng ,  Maria T. Arevalo

IPC: C12N15/113 ,  C07K16/28

CPC classification number: C12N15/1138 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/30

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

Abstract translation: 本发明包括阻断TEM8和/或CMG2细胞表面蛋白质和炭疽毒素之间的相互作用的siRNA和抗体以及用其处理炭疽暴露的方法。

公开(公告)号：US10370416B2

公开(公告)日：2019-08-06

申请号：US15446315

申请日：2017-03-01

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo ,  Junwei Li

IPC: C07K14/005 ,  G01N33/50 ,  A61K39/07 ,  A61K39/12 ,  A61K39/00

Abstract: The present invention includes antigenic fusion proteins, nucleic acids encoding the fusion proteins and methods of making and using the same, wherein the fusion protein comprises three or more different influenza A ectodomains of Matrix Protein 2 (M2e); one or more stem regions of an influenza A hemagglutinin 2 (HA2) protein; and optionally an anthrax antigen, wherein the fusion protein is immunogenic across strains.

公开(公告)号：US20180187191A1

公开(公告)日：2018-07-05

申请号：US15736358

申请日：2016-06-15

Applicant: Texas Tech University System

Inventor： Mingtao Zeng

IPC: C12N15/113 ,  A61P31/04 ,  A61K47/64

CPC classification number: C12N15/113 ,  A61K31/7105 ,  A61K35/742 ,  A61K38/164 ,  A61K47/6415 ,  A61P31/04 ,  C12N2310/14 ,  A61K2300/00

Abstract: The present invention includes a composition for the targeted-delivery of small interference RNA against bacteria comprising: a detoxified bacterial protein toxin that comprises a highly positively charged region; and an siRNA that is specific to, and knocks-down expression of one or more genes related to one or more virulence factors of the bacteria, wherein the siRNA is bound to the highly positively charged region of the detoxified bacterial protein toxin.

公开(公告)号：US09862951B2

公开(公告)日：2018-01-09

申请号：US14898179

申请日：2014-06-12

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo

IPC: C12N15/113 ,  C07K16/28

CPC classification number: C12N15/1138 ,  C07K16/28 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2310/14 ,  C12N2320/30

Abstract: The present invention includes siRNAs and antibodies that block the interaction between TEM8 and/or CMG2 cell surface proteins and anthrax toxin and methods of treating anthrax exposure with the same.

公开(公告)号：US20170253636A1

公开(公告)日：2017-09-07

申请号：US15446315

申请日：2017-03-01

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Maria T. Arevalo ,  Junwei Li

IPC: C07K14/005 ,  G01N33/50 ,  A61K39/145

CPC classification number: C07K14/005 ,  A61K39/07 ,  A61K39/12 ,  A61K2039/543 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/40 ,  C07K2319/55 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16162 ,  G01N33/5023 ,  G01N33/5088 ,  G01N2333/11 ,  G01N2333/32

Abstract: The present invention includes antigenic fusion proteins, nucleic acids encoding the fusion proteins and methods of making and using the same, wherein the fusion protein comprises three or more different influenza A ectodomains of Matrix Protein 2 (M2e); one or more stem regions of an influenza A hemagglutinin 2 (HA2) protein; and optionally an anthrax antigen, wherein the fusion protein is immunogenic across strains.

公开(公告)号：US11946047B2

公开(公告)日：2024-04-02

申请号：US16660986

申请日：2019-10-23

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Lihong Wu

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2320/32

Abstract: The present invention includes a composition and method for decreasing Bacillus anthracis virulence or toxicity comprising: at least one inhibitor that decreases an expression of one or more host genes selected from G6pc, Rgs1, Fosl2, Hcar2, Cxcl2 and Cxcl3, or Serpine1 (PAI-1).

公开(公告)号：US10286062B2

公开(公告)日：2019-05-14

申请号：US14903611

申请日：2014-07-09

Applicant: Texas Tech University System

Inventor： Mingtao Zeng ,  Junwei Li

IPC: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00 ,  G01N33/569 ,  A61K39/00

Abstract: The present invention includes an isolated antigen against influenza A and a method of making the same that includes an ectodomain of influenza A Matrix Protein 2 (M2e) and a stem region of an influenza A hemagglutinin 2 (HA2) protein and an adjuvant. The invention further includes formulating the antigen into an isolated immune response stimulating fusion protein and/or a vaccine.