公开(公告)号：US12202785B2

公开(公告)日：2025-01-21

申请号：US18059533

申请日：2022-11-29

Applicant: Texas Tech University System

Inventor： Susan E. Bergeson ,  Peter Syapin ,  Ted W. Reid ,  Mayank Shastri ,  Phat Tran

IPC: C07C237/26 ,  A61B5/00 ,  A61K31/65 ,  C07D317/72

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

公开(公告)号：US20230127462A1

公开(公告)日：2023-04-27

申请号：US18059533

申请日：2022-11-29

Applicant: Texas Tech University System

Inventor： Susan E. Bergeson ,  Peter Syapin ,  Ted W. Reid ,  Mayank Shastri ,  Phat Tran

IPC: C07C237/26 ,  A61B5/00 ,  C07D317/72 ,  A61K31/65

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.