公开(公告)号：US20250050283A1

公开(公告)日：2025-02-13

申请号：US18930686

申请日：2024-10-29

Applicant: Texas Tech University System

Inventor： Wei LI ,  Rutwik JOSHI ,  Gizem LEVENT

IPC: B01D71/04 ,  B01D67/00 ,  C01B3/00 ,  C01B3/50 ,  C03B19/10 ,  C03C11/00

Abstract: Hollow glass microspheres (HGMS) with a controlled nanotopographical surface structure (NSHGMS) demonstrate improved isolation and recovery of cells and other biological particles such as bacteria from biological fluid. Such functionalized HGMS are formed by exposing a plurality of hollow glass microspheres to a layer by layer deposition cycle of charged polymeric nanofilms to form a plurality of coated hollow glass microspheres and functionally binding a plurality of biotinylated antibodies to the plurality of coated hollow glass microspheres. Application of these HGMS in related biological particle isolation methods does not require specialized lab equipment or an external power source, and thus, can be used for separation of targeted cells from blood or other fluid in a resource-limited environment.