公开(公告)号：US20250084091A1

公开(公告)日：2025-03-13

申请号：US18558908

申请日：2022-05-04

Applicant: The Texas A&M University System

Inventor： James C. Sacchettini ,  Nian E. Zhou ,  Maloy Kumar Parai ,  Joonyoung Shin ,  Jeremy Lee Wood ,  Inna V. Krieger ,  Armando Flores ,  Arjun Acharya ,  Zhe Shi ,  Xuelin Bian ,  Su TANG ,  Radha Bam ,  Pradeep Kumar Jaiswal

IPC: C07D487/08 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/55 ,  A61K45/06 ,  C07D213/82 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04 ,  C07D519/00

Abstract: Described herein are compounds and methods for the treatment of coronavirus infection. The compounds can function as an inhibitor of the main protease (Mpro) of coronaviruses. The compounds can include diphenylmethyl piperazine derivatives, diphenylmethyl piperidine derivatives, diphenylmethylidene piperidine derivatives, tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen derivatives, tricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen derivatives, 6,11-dihydrobenzo[c][1]benzoxepin derivatives, 6,11-dihydrobenzo[c][1]benzothiepin derivatives, 5,5-dioxo-6,11-dihydrobenzo[c][1]benzothiepin derivatives, and 6-oxo-5,11-dihydrobenzo[c][1]benzazepin derivatives, as well as pharmaceutically acceptable salts, hydrates, and prodrugs thereof.