公开(公告)号：US20180296492A1

公开(公告)日：2018-10-18

申请号：US15986186

申请日：2018-05-22

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： Bjoern Markus Reinhard ,  Suryaram Gummuluru

IPC: A61K9/51 ,  G01N33/50 ,  B82Y5/00 ,  A61K9/127 ,  A61K47/69 ,  A61B5/055 ,  A61K47/54 ,  A61K47/61

Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.

公开(公告)号：US10646451B2

公开(公告)日：2020-05-12

申请号：US15986186

申请日：2018-05-22

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： Bjoern Markus Reinhard ,  Suryaram Gummuluru

IPC: A61K9/51 ,  A61K9/127 ,  B82Y5/00 ,  A61B5/055 ,  G01N33/50 ,  A61K47/69 ,  A61K47/61 ,  A61K47/54

Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.

公开(公告)号：US20150185370A1

公开(公告)日：2015-07-02

申请号：US14657279

申请日：2015-03-13

Applicant: Trustees of Boston University

Inventor： Bjoern Markus Reinhard ,  Luca Dal Negro

IPC: G02B5/00 ,  G01N21/65 ,  G01N21/01

CPC classification number: G02B5/008 ,  B82Y30/00 ,  C03C17/40 ,  C03C2217/255 ,  C03C2217/425 ,  G01N21/01 ,  G01N21/658 ,  G01N2201/02 ,  Y10T428/12104 ,  Y10T428/24909

Abstract: Defined nanoparticle cluster arrays (NCAs) with dimensions up to 25.4 μm square are fabricated on a 10 nm gold film using template guided self-assembly. Structural parameters are precisely controlled, allowing systematic variation of the number of nanoparticles in the clusters (n) and edge to edge separation (Λ) between 1

Abstract translation: 使用模板引导的自组装在10nm金膜上制造尺寸高达25.4μm正方形的定义的纳米颗粒簇阵列（NCAs）。 结构参数被精确控制，允许分别在1

公开(公告)号：US11504338B2

公开(公告)日：2022-11-22

申请号：US16844526

申请日：2020-04-09

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： Bjoern Markus Reinhard ,  Suryaram Gummuluru

IPC: A61K9/51 ,  A61K9/127 ,  B82Y5/00 ,  A61B5/055 ,  G01N33/50 ,  A61K47/69 ,  A61K47/61 ,  A61K47/54

Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.

公开(公告)号：US20180128947A1

公开(公告)日：2018-05-10

申请号：US15840834

申请日：2017-12-13

Applicant: Trustees of Boston University

Inventor： Bjoern Markus Reinhard ,  Luca Dal Negro

IPC: G02B5/00 ,  B82Y30/00 ,  C03C17/40 ,  G01N21/01 ,  G01N21/65

CPC classification number: G02B5/008 ,  B82Y30/00 ,  C03C17/40 ,  C03C2217/255 ,  C03C2217/425 ,  G01N21/01 ,  G01N21/658 ,  G01N2201/02 ,  Y10T428/12104 ,  Y10T428/24909

Abstract: Defined nanoparticle cluster arrays (NCAs) with dimensions up to 25.4 μm square are fabricated on a 10 nm gold film using template guided self-assembly. Structural parameters are precisely controlled, allowing systematic variation of the number of nanoparticles in the clusters (n) and edge to edge separation (∧) between 1

公开(公告)号：US20210128489A1

公开(公告)日：2021-05-06

申请号：US16844526

申请日：2020-04-09

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： Bjoern Markus Reinhard ,  Suryaram Gummuluru

IPC: A61K9/51 ,  A61K9/127 ,  B82Y5/00 ,  A61B5/055 ,  G01N33/50 ,  A61K47/69 ,  A61K47/61 ,  A61K47/54

Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.

公开(公告)号：US10004695B2

公开(公告)日：2018-06-26

申请号：US15304127

申请日：2015-04-08

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： Bjoern Markus Reinhard ,  Suryaram Gummuluru

IPC: A61K9/127 ,  A61K9/51 ,  B82Y5/00 ,  A61B5/055 ,  A61K47/48 ,  G01N33/50

CPC classification number: A61K9/5123 ,  A61B5/055 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/5115 ,  A61K9/5192 ,  A61K47/543 ,  A61K47/61 ,  A61K47/6911 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00 ,  G01N33/5005

Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.

公开(公告)号：US20170042824A1

公开(公告)日：2017-02-16

申请号：US15304127

申请日：2015-04-08

Applicant: TRUSTEES OF BOSTON UNIVERSITY

Inventor： Bjoern Markus Reinhard ,  Suryaram Gummuluru

IPC: A61K9/51 ,  G01N33/50 ,  A61K47/48

CPC classification number: A61K9/5123 ,  A61B5/055 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/5115 ,  A61K9/5192 ,  A61K47/543 ,  A61K47/61 ,  A61K47/6911 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00 ,  G01N33/5005

Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nano-particles are endocytosed by the CD169+ expressing cells.

Abstract translation: 本文公开的实施方案涉及总体尺寸在60-100nm之间的含神经节苷脂GM3的混合脂质纳米颗粒，其制备和用途。 纳米颗粒选择性靶向CD169 +表达细胞，如树突状细胞和巨噬细胞。 纳米颗粒被表达CD169 +的细胞内吞。