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    ANTI-IgE ANTIBODIES
    1.
    发明申请
    ANTI-IgE ANTIBODIES 审中-公开

    公开(公告)号：US20190144565A1

    公开(公告)日：2019-05-16

    申请号：US16307454

    申请日：2017-06-08

    Applicant: UCB BIOPHARMA SPRL

    Inventor： Ralph ADAMS ,  Thomas Allen CESKA ,  Anna Marie DAVIES ,  Alistair James HENRY ,  Xiaofeng LIU ,  James Michael MCDONNELL ,  Brian John SUTTON ,  Marta Katarzyna WESTWOOD

    IPC: C07K16/42 ,  C07K16/28 ,  A61P37/08

    Abstract: The present invention relates to the area of improved anti-IgE antibodies and antigen binding agents, and compositions thereof, which target IgE, for instance: for use in treating disorders caused by IgE (such as allergic responses, or certain autoimmune responses); and, in particular, disorders caused by the interaction of IgE with the FcεRI receptor. In particular, this invention relates to improved anti-IgE antibodies and antigen binding agents related to novel mutants of omalizumab (Xolair®). The improved anti-IgE antibodies and antigen binding agents of the invention may have improved affinity for IgE and/or an improved interaction with the Cε2 domain of IgE and/or an improved modified epitope on IgE (for instance further involving the Cε2 domain of IgE) and/or the ability to disassociate IgE from the FcεRI receptor for instance at pharmaceutically-relevant concentrations. In one aspect, improved or novel treatments for IgE mediated disorders are disclosed in which IgE is targeted (for instance free IgE and/or IgE complexed with the FcεRI receptor).

    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    2.
    发明申请
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权

    公开(公告)号：US20180134774A1

    公开(公告)日：2018-05-17

    申请号：US15795874

    申请日：2017-10-27

    Applicant: UCB Biopharma SPRL

    Inventor： Ralph ADAMS ,  Pallavi BHATTA ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS

    IPC: C07K16/18 ,  C07K16/28

    CPC classification number: C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

    Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

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