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    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF
    1.
    发明申请
    ALBUMIN BINDING ANTIBODIES AND BINDING FRAGMENTS THEREOF 有权

    公开(公告)号：US20180134774A1

    公开(公告)日：2018-05-17

    申请号：US15795874

    申请日：2017-10-27

    Applicant: UCB Biopharma SPRL

    Inventor： Ralph ADAMS ,  Pallavi BHATTA ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS

    IPC: C07K16/18 ,  C07K16/28

    CPC classification number: C07K16/18 ,  C07K16/2878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/624 ,  C07K2317/92

    Abstract: A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in SEQ ID NO: 1 or SEQ ID NO:2 and/or comprising a light chain variable domain having the sequence given in SEQ ID NO:3 or SEQ ID NO:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 1 and SEQ ID NO:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in SEQ ID NO: 2 and SEQ ID NO:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. The disclosure further includes pharmaceutical compositions comprising the antibodies or fragments and therapeutic used of any one of the same.

    MULTISPECIFIC ANTIBODY CONSTRUCTS
    3.
    发明申请
    MULTISPECIFIC ANTIBODY CONSTRUCTS 审中-公开

    公开(公告)号：US20170204200A1

    公开(公告)日：2017-07-20

    申请号：US15321055

    申请日：2015-06-25

    Applicant: UCB BIOPHARMA SPRL

    Inventor： Pallavi BHATTA ,  Emma DAVE ,  Sam Philip HEYWOOD ,  David Paul HUMPHREYS

    IPC: C07K16/46

    Abstract: The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (I): VH—CH1—X—V1; and b) a polypeptide chain of formula (II): VL-CL-Y—V2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. There is a provided a method of expressing a multispecific antibody molecule of the present disclosure from a host cell.

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