公开(公告)号：US10105359B2

公开(公告)日：2018-10-23

申请号：US15517795

申请日：2015-10-06

Applicant: UCB Biopharma SPRL

Inventor： Anne Valade ,  Eric Jnoff ,  Ali Ates ,  Pierre Burssens ,  David Skolc ,  Zara Sands ,  Benoit Mathieu

IPC: C07D217/06 ,  A61K31/4725 ,  C07D401/06 ,  C07D403/06 ,  C07D413/04

Abstract: The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.