公开(公告)号：US10105359B2

公开(公告)日：2018-10-23

申请号：US15517795

申请日：2015-10-06

Applicant: UCB Biopharma SPRL

Inventor： Anne Valade ,  Eric Jnoff ,  Ali Ates ,  Pierre Burssens ,  David Skolc ,  Zara Sands ,  Benoit Mathieu

IPC: C07D217/06 ,  A61K31/4725 ,  C07D401/06 ,  C07D403/06 ,  C07D413/04

Abstract: The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US09975873B2

公开(公告)日：2018-05-22

申请号：US15517769

申请日：2015-10-06

Applicant: UCB Biopharma SPRL

Inventor： David Skolc ,  Ali Ates ,  Eric Jnoff ,  Anne Valade ,  Benoit Mathieu ,  Zara Sands

IPC: C07D401/06 ,  A61K31/4035 ,  C07D209/44 ,  C07D487/04

CPC classification number: C07D401/06 ,  A61K31/4035 ,  C07D209/44 ,  C07D487/04

Abstract: The present invention relates to isoindoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US20170313677A1

公开(公告)日：2017-11-02

申请号：US15517769

申请日：2015-10-06

Applicant: UCB Biopharma SPRL

Inventor： David Skolc ,  Ali Ates ,  Eric Jnoff ,  Anne Valade ,  Benoit Mathieu ,  Zara Sands

IPC: C07D401/06 ,  C07D209/44 ,  C07D487/04 ,  A61K31/4035

CPC classification number: C07D401/06 ,  A61K31/4035 ,  C07D209/44 ,  C07D487/04

Abstract: The present invention relates to isoindoline derivatives according to formula (I), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.