公开(公告)号：US20230168174A1

公开(公告)日：2023-06-01

申请号：US17927622

申请日：2021-04-19

Applicant: UNIVERSITÄT HAMBURG ,  UNIVERSITÄTSKLINIKUM HAMBURG-EPPENDORF

Inventor： Robert BLICK ,  Paul GWOZDZ ,  Udai Raj SINGH ,  Andreas GUSE ,  Lola HERNANDEZ ,  Björn-Philipp DIERCKS

IPC: G01N15/10 ,  G01N22/00 ,  G01N15/02

CPC classification number: G01N15/1031 ,  G01N22/00 ,  G01N15/0266 ,  G01N15/1056 ,  G01N2015/0065

Abstract: Provided is a label-free, single biological cell dielectric spectroscopy method, including the steps of: translocating a biological cell through a micropore or channel embedded in a substrate and interfaced with a coplanar waveguide while the biological cell experiences at least one RF field of at least 700 MHz provided via an RF input port to the coplanar waveguide; performing a time domain measurement of at least one RF signal reflected from or transmitted to a device under test (DUT); and determining an amplitude change and a phase change based on the reflected or transmitted at least one RF signal due to the translocating biological cell to determine an internal state or a morphological state of the biological cell. Also disclosed herein are devices for performing the dielectric spectroscopy method.

公开(公告)号：US20230152473A1

公开(公告)日：2023-05-18

申请号：US17916165

申请日：2021-03-30

Applicant: UNIVERSITÄT HAMBURG

Inventor： Robert BLICK ,  Stefanie HAUGG ,  Robert ZIEROLD

IPC: G01T1/16 ,  H01J43/24 ,  H01J9/02 ,  B33Y80/00 ,  B33Y10/00 ,  B29C64/124

CPC classification number: G01T1/16 ,  B29C64/124 ,  B33Y10/00 ,  B33Y80/00 ,  H01J9/02 ,  H01J43/246 ,  B29L2031/40

Abstract: A microchannel sensor for detecting radiation and/or particles, the microchannel sensor comprising at least one sensor substrate, wherein said sensor substrate comprises a plurality of channels extending from a first side of the substrate to an opposite side of the substrate, wherein said channels are arranged along a channel axis which is tilted relative a normal axis of said substrate, and wherein said plurality of channels comprise a first set of channels with a first cross section and a second set of channels with a second cross section being different from said first cross section.

公开(公告)号：US20210072220A1

公开(公告)日：2021-03-11

申请号：US16632296

申请日：2018-07-16

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  UNIVERSITÄT HAMBURG

Inventor： Robert BLICK ,  Paul GWOZDZ ,  Abhishek BHAT

IPC: G01N33/487 ,  G01N33/58 ,  C12Q1/6869

Abstract: A method to determine the throughput speed v of a pore, comprising the steps of feeding, by means of a driving force F, a filiform calibration element through the pore, the calibration element having a plurality of markers spaced apart by known distances and configured to produce an interaction event that transmits a signal away from the pore upon interaction with the pore, detecting a plurality of interaction events, and determining a time interval Δt between successive interaction events, and/or a frequency ω of interaction events.

公开(公告)号：US20230191691A1

公开(公告)日：2023-06-22

申请号：US17916160

申请日：2021-03-30

Applicant: UNIVERSITÄT HAMBURG

Inventor： Robert BLICK ,  Stefanie HAUGG ,  Robert ZIEROLD

IPC: B29C64/135 ,  B29C64/176 ,  B29C64/264 ,  B29C64/393

CPC classification number: B29C64/135 ,  B29C64/176 ,  B29C64/264 ,  B29C64/393 ,  B33Y10/00

Abstract: A method of step-wise exposing a voxel of a resist to radiation for forming a three-dimensional structure, the method comprising setting a step size to a first resolution; setting a voxel volume to a first volume; exposing a first set of voxels of said first volume to radiation using said first resolution; setting the step size to a second resolution being smaller than said first resolution, or, respectively, greater than said first resolution; setting the voxel volume to a second volume being smaller than said first volume, or, respectively, greater than said first volume; and exposing a second set of voxels of said second volume to radiation using said second resolution.