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公开(公告)号：US20140363900A1
公开(公告)日：2014-12-11
申请号：US14363778
申请日：2012-12-05
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Jonathan Lovell , Elizabeth Huynh
CPC classification number: C12Q1/6806 , A61K41/0028 , B01J13/02 , C12N11/04 , C12N13/00 , C12N15/88 , C12P1/00 , G01N1/28 , Y10T436/143333
Abstract: There is provided herein vesicles comprising a bilayer comprising porphyrin-phospholipid conjugate, wherein the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipids, wherein the vesicle is 1-100 microns in diameter.
Abstract translation: 提供了包含包含卟啉 - 磷脂缀合物的双层的囊泡，其中卟啉 - 磷脂缀合物包含共价连接到脂质侧链上的卟啉，卟啉衍生物或卟啉类似物，优选在sn-1或sn-2位， 的一种磷脂，其中囊泡的直径为1-100微米。
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公开(公告)号：US20170319719A1
公开(公告)日：2017-11-09
申请号：US15661125
申请日：2017-07-27
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Elizabeth Huynh , Kenneth Ng , Mojdeh Shakiba , Robert Weersink , Brian Wilson
CPC classification number: A61K49/227 , A61K49/0036 , A61K49/0052 , A61K49/0084 , A61K49/221
Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.
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公开(公告)号：US20150359912A1
公开(公告)日：2015-12-17
申请号：US14764403
申请日：2014-01-28
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Elizabeth Huynh , Kenneth Ng , Mojdeh Shakiba , Robert Weersink , Brian Wilson
CPC classification number: A61K49/227 , A61K49/0036 , A61K49/0052 , A61K49/0084 , A61K49/221
Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.
Abstract translation: 本文提供了具有包含饱和第一磷脂和不超过约15摩尔％的与J-骨料形成染料共价缀合的第二磷脂的双层的纳米囊。
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公开(公告)号：US20140257100A1
公开(公告)日：2014-09-11
申请号：US14351354
申请日：2012-10-11
Applicant: UNIVERSITY HEALTH NETWORK
Inventor： Gang Zheng , Jonathan Lovell , Elizabeth Huynh
CPC classification number: A61B8/481 , A61B5/0095 , A61K9/14 , A61K47/22 , A61K47/24 , A61K49/048 , A61K49/223
Abstract: The present invention relates to a microbubble comprising a monolayer of porphyrin-phospholipid conjugate, said microbubble having encapsulated therein, and to the use of said microbubble in ultrasound imaging of a target area in a subject.
Abstract translation: 本发明涉及包含单层卟啉 - 磷脂缀合物的微泡，所述微泡封装在其中，以及所述微泡在受试者的靶区域的超声成像中的用途。
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