公开(公告)号：US11572354B2

公开(公告)日：2023-02-07

申请号：US16961112

申请日：2019-01-09

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Donald Weaver ,  Michael G. Brant ,  Stephanie Wohnig ,  Fan Wu ,  Jake Goodwin-Tindall ,  Autumn Meek ,  Paolo Schiavini

IPC: C07D403/14 ,  C07D403/04 ,  C07D401/14

Abstract: Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of Formula (Ia) and (Ib) of IDO, their synthesis, and uses thereof are provided.