公开(公告)号：US20230227821A1

公开(公告)日：2023-07-20

申请号：US17916981

申请日：2021-04-07

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Daniel DINIZ DE CARVALHO ,  Housheng HE ,  Ilias ETTAYEBI ,  Fraser SOARES ,  Helen LOO YAU

IPC: C12N15/113 ,  C12N5/0783 ,  A61K35/17 ,  A61P35/00

CPC classification number: C12N15/113 ,  C12N5/0636 ,  A61K35/17 ,  A61P35/00 ,  C12N2310/20

Abstract: Methods of increasing T cell effector function in a T cell population are provided that involve inhibiting one or more genetic subunits of the SAGA (Spt-Ada-Gcn5-acetyltransferase) gene regulation complex in the T cell population. Also provided are methods of using such T cell populations in the treatment of cancer patients.