公开(公告)号：US20230265079A1

公开(公告)日：2023-08-24

申请号：US18096397

申请日：2023-01-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Donald WEAVER ,  Michael G. BRANT ,  Stephanie WOHNIG ,  Fan WU ,  Jake GOODWIN-TINDALL ,  Autumn MEEK ,  Paolo SCHIAVINI

IPC: C07D403/04 ,  C07D401/14

CPC classification number: C07D403/04 ,  C07D401/14

Abstract: Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of IDO, syntheses, and uses thereof are provided.