公开(公告)号：US20230265524A1

公开(公告)日：2023-08-24

申请号：US18008053

申请日：2021-06-03

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Daniel DINIZ DE CARVALHO ,  Parinaz MEHDIPOUR ,  Sajid MARHON

IPC: C12Q1/6886 ,  A61K31/706 ,  A61P35/00

CPC classification number: C12Q1/6886 ,  A61K31/706 ,  A61P35/00 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/154

Abstract: There is described herein a method of assessing a subject's responsiveness to cancer therapy, comprising: providing a sample from the subject comprising cancers cells or suspected cancer cells; measuring or estimating the expression levels of inverted repeats (IR) Alus in the cells; and determining that the subject would be responsive to 5 cancer therapy if the subject cells exhibit expression levels of inverted repeats (IR) Alus with reference to expression levels in control samples.