公开(公告)号：US20180282335A1

公开(公告)日：2018-10-04

申请号：US15521895

申请日：2015-10-09

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Richard Brokx ,  Heinz W. Pauls ,  Sze-wan Li ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07D487/04 ,  A61P35/00 ,  A61P29/00 ,  A61P37/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06

Abstract: The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).

公开(公告)号：US10239881B2

公开(公告)日：2019-03-26

申请号：US15521895

申请日：2015-10-09

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Richard Brokx ,  Heinz W. Pauls ,  Sze-wan Li ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P37/06 ,  A61P29/00 ,  A61P35/00

Abstract: The invention is a compound represented by Structural Formula (I): (I); or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).

公开(公告)号：US20220089725A1

公开(公告)日：2022-03-24

申请号：US17430311

申请日：2020-02-14

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Richard Brokx ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07K16/28 ,  A61P35/02 ,  C12N15/63

Abstract: The invention provides novel anti-FCMR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.

公开(公告)号：US20190225617A1

公开(公告)日：2019-07-25

申请号：US16258753

申请日：2019-01-28

Applicant: University Health Network

Inventor： Radoslaw Laufer ,  Grace Ng ,  Richard Brokx ,  Heinz W. Pauls ,  Sze-Wan Li ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07D487/04 ,  A61P35/00 ,  A61P29/00 ,  A61K31/519 ,  A61K45/06 ,  A61P37/06

Abstract: The invention is a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).

公开(公告)号：US12286476B2

公开(公告)日：2025-04-29

申请号：US17430311

申请日：2020-02-14

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Richard Brokx ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07K16/28 ,  A61P35/02 ,  C12N15/63

Abstract: The invention provides novel anti-FCMR antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.

公开(公告)号：US20220153834A1

公开(公告)日：2022-05-19

申请号：US17434368

申请日：2020-03-11

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Richard Brokx ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07K16/28 ,  A61P35/00

Abstract: The invention provides novel anti-TSG-6 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer or autoimmune disease.

公开(公告)号：US20220089723A1

公开(公告)日：2022-03-24

申请号：US17421705

申请日：2020-01-16

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Richard Brokx ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07K16/28

Abstract: The invention provides novel anti-LILRB3 antibodies, pharmaceutical compositions comprising such antibodies, and therapeutic methods of using such antibodies and pharmaceutical compositions for the treatment of diseases such as cancer, autoimmune disease, or allergic inflammation This invention can also be used to modulate osteoclast differentiation.

公开(公告)号：US20210261554A1

公开(公告)日：2021-08-26

申请号：US17134270

申请日：2020-12-26

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Radoslaw Laufer ,  Grace Ng ,  Richard Brokx ,  Heinz W. Pauls ,  Sze-Wan Li ,  Jacqueline M. Mason ,  Mark R. Bray

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61P37/06 ,  A61P29/00 ,  A61P35/00

Abstract: The invention is a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Values for the variables are provided herein. Also included is a pharmaceutical composition comprising the compound represented by Structural Formula (I) and a pharmaceutically acceptable carrier or diluent and methods of treating a subject with cancer with the compound of Structural Formula (I).