公开(公告)号：US20250009912A1

公开(公告)日：2025-01-09

申请号：US18896069

申请日：2024-09-25

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Christopher Pigge ,  Mengshi Li ,  Moustafa Gabr ,  Edwin Sagastume

IPC: A61K51/04 ,  A61K45/06 ,  A61K51/08

Abstract: A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa; each of R5-R12 is independently selected from the group consisting of II and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.

公开(公告)号：US12128115B2

公开(公告)日：2024-10-29

申请号：US17051037

申请日：2019-04-25

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Christopher Pigge ,  Mengshi Li ,  Moustafa Gabr ,  Edwin Sagastume

IPC: A61K51/04 ,  A61K45/06 ,  A61K51/08

CPC classification number: A61K51/0482 ,  A61K45/06 ,  A61K51/0497 ,  A61K51/083

Abstract: A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa; each of R5-R12 is independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.

公开(公告)号：US20210228749A1

公开(公告)日：2021-07-29

申请号：US17051037

申请日：2019-04-25

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Michael K. Schultz ,  Christopher Pigge ,  Mengshi Li ,  Moustafa Gabr ,  Edwin Sagastume

IPC: A61K51/04 ,  A61K51/08 ,  A61K45/06

Abstract: A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa; each of R5-R12 is independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.