公开(公告)号：US20190284544A1

公开(公告)日：2019-09-19

申请号：US16340657

申请日：2017-10-02

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Vinit B. Mahajan ,  Alexander G. Bassuk ,  Diana F. Colgan ,  Gabriel Velez ,  Kellie Schaefer ,  Marcus Toral ,  Shu Wu ,  Lokesh Gakhar

IPC: C12N9/64 ,  G01N33/573 ,  A61P27/02 ,  C07K14/81 ,  A61K9/08 ,  A61P29/00 ,  C07K14/49

Abstract: The present disclosure provides CAPN5 substrates and CAPN5 inhibitors, nucleic acids encoding CAPN5 substrates or CAPN5 inhibitors, methods to deliver CAPN5 substrate or CAPN5 inhibitor agents to the eye, and methods of identifying inhibitors of CAPN5.

公开(公告)号：US11981943B2

公开(公告)日：2024-05-14

申请号：US16340657

申请日：2017-10-02

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Vinit B. Mahajan ,  Alexander G. Bassuk ,  Diana F. Colgan ,  Gabriel Velez ,  Kellie Schaefer ,  Marcus Toral ,  Shu Wu ,  Lokesh Gakhar

IPC: C12N9/64 ,  A61K9/08 ,  A61K38/00 ,  A61P27/02 ,  A61P29/00 ,  C07K14/49 ,  C07K14/81 ,  G01N33/573 ,  C07K7/64

CPC classification number: C12N9/6472 ,  A61K9/08 ,  A61P27/02 ,  A61P29/00 ,  C07K14/49 ,  C07K14/81 ,  C07K14/8139 ,  C12Y304/22 ,  G01N33/573 ,  A61K38/00 ,  C07K7/64 ,  C07K2319/00

Abstract: The present disclosure provides CAPN5 substrates and CAPN5 inhibitors, nucleic acids encoding CAPN5 substrates or CAPN5 inhibitors, methods to deliver CAPN5 substrate or CAPN5 inhibitor agents to the eye, and methods of identifying inhibitors of CAPN5.

公开(公告)号：US20220364142A1

公开(公告)日：2022-11-17

申请号：US17767280

申请日：2020-10-09

Applicant: The Board of Trustees of the Leland Stanford Junior University ,  The United States Government as represented by the Department of Veterans Affairs ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Vinit Mahajan ,  Gabriel Velez ,  Young Joo Sun ,  Kellie A Schaefer ,  Alexander G Bassuk

IPC: C12Q1/37 ,  A61K49/00 ,  A61K45/06

Abstract: Compositions, methods, and kits are provided for assaying calpain-5 activity and inhibition. In particular, novel peptide substrates are provided for detecting calpain-5, measuring calpain-5 activity, and screening for inhibitors of calpain-5 to identify potential therapeutic agents for treating retinal diseases and other diseases associated with calpain-5 hyperactivity. Additionally, novel inhibitors of calpain-5 are also provided.