公开(公告)号：US11981943B2

公开(公告)日：2024-05-14

申请号：US16340657

申请日：2017-10-02

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Vinit B. Mahajan ,  Alexander G. Bassuk ,  Diana F. Colgan ,  Gabriel Velez ,  Kellie Schaefer ,  Marcus Toral ,  Shu Wu ,  Lokesh Gakhar

IPC: C12N9/64 ,  A61K9/08 ,  A61K38/00 ,  A61P27/02 ,  A61P29/00 ,  C07K14/49 ,  C07K14/81 ,  G01N33/573 ,  C07K7/64

CPC classification number: C12N9/6472 ,  A61K9/08 ,  A61P27/02 ,  A61P29/00 ,  C07K14/49 ,  C07K14/81 ,  C07K14/8139 ,  C12Y304/22 ,  G01N33/573 ,  A61K38/00 ,  C07K7/64 ,  C07K2319/00

Abstract: The present disclosure provides CAPN5 substrates and CAPN5 inhibitors, nucleic acids encoding CAPN5 substrates or CAPN5 inhibitors, methods to deliver CAPN5 substrate or CAPN5 inhibitor agents to the eye, and methods of identifying inhibitors of CAPN5.

公开(公告)号：US20190284544A1

公开(公告)日：2019-09-19

申请号：US16340657

申请日：2017-10-02

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Vinit B. Mahajan ,  Alexander G. Bassuk ,  Diana F. Colgan ,  Gabriel Velez ,  Kellie Schaefer ,  Marcus Toral ,  Shu Wu ,  Lokesh Gakhar

IPC: C12N9/64 ,  G01N33/573 ,  A61P27/02 ,  C07K14/81 ,  A61K9/08 ,  A61P29/00 ,  C07K14/49

Abstract: The present disclosure provides CAPN5 substrates and CAPN5 inhibitors, nucleic acids encoding CAPN5 substrates or CAPN5 inhibitors, methods to deliver CAPN5 substrate or CAPN5 inhibitor agents to the eye, and methods of identifying inhibitors of CAPN5.