公开(公告)号：US20240084163A1

公开(公告)日：2024-03-14

申请号：US18507969

申请日：2023-11-13

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Elise Lin Cheng ,  C. Allan Guymon ,  Marlan R. Hansen ,  Braden Leigh

IPC: C09D133/10 ,  A61L27/16 ,  A61L27/34 ,  A61L29/04 ,  A61L29/08 ,  A61L31/04 ,  A61L31/10 ,  C08K5/11 ,  C09D5/16 ,  C09D133/26 ,  C09D151/08

CPC classification number: C09D133/10 ,  A61L27/16 ,  A61L27/34 ,  A61L29/041 ,  A61L29/085 ,  A61L31/048 ,  A61L31/10 ,  C08K5/11 ,  C09D5/1675 ,  C09D133/26 ,  C09D151/085 ,  A61L2300/404 ,  A61L2420/08

Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

公开(公告)号：US20190282803A1

公开(公告)日：2019-09-19

申请号：US15759643

申请日：2016-06-24

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Marlan R. Hansen ,  Christopher Kaufmann

IPC: A61N1/05 ,  A61N1/36 ,  A61B17/34 ,  H01L41/09 ,  H04B5/00

Abstract: The present embodiment is an implantable device capable of controlling cochlear implant electrode insertion and positioning. The embodiment uses an implanted mechanical positioning unit to advance position and monitor an electrode array. The device can be controlled via an external controller to reposition or advance an electrode array at any point after implantation with no surgical re-intervention. A cochlear implant electrode array whose position can be advanced and modified over time to best fit a patient's evolving hearing pattern would improve functional outcomes and significantly expand the candidacy range for cochlear implantation to include patients with substantial residual hearing.

公开(公告)号：US11241576B2

公开(公告)日：2022-02-08

申请号：US15759643

申请日：2016-06-24

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Marlan R. Hansen ,  Christopher Kaufmann

IPC: A61N1/05 ,  A61N1/36 ,  A61B17/34 ,  H01L41/09 ,  H04B5/00

Abstract: The present embodiment is an implantable device capable of controlling cochlear implant electrode insertion and positioning. The embodiment uses an implanted mechanical positioning unit to advance position and monitor an electrode array. The device can be controlled via an external controller to reposition or advance an electrode array at any point after implantation with no surgical re-intervention. A cochlear implant electrode array whose position can be advanced and modified over time to best fit a patient's evolving hearing pattern would improve functional outcomes and significantly expand the candidacy range for cochlear implantation to include patients with substantial residual hearing.

公开(公告)号：US12116498B2

公开(公告)日：2024-10-15

申请号：US18507969

申请日：2023-11-13

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Elise Lin Cheng ,  C. Allan Guymon ,  Marlan R. Hansen ,  Braden Leigh

IPC: C09D133/10 ,  A61L27/16 ,  A61L27/34 ,  A61L29/04 ,  A61L29/08 ,  A61L31/04 ,  A61L31/10 ,  C08K5/11 ,  C09D5/16 ,  C09D133/26 ,  C09D151/08

CPC classification number: C09D133/10 ,  A61L27/16 ,  A61L27/34 ,  A61L29/041 ,  A61L29/085 ,  A61L31/048 ,  A61L31/10 ,  C08K5/11 ,  C09D5/1675 ,  C09D133/26 ,  C09D151/085 ,  A61L2300/404 ,  A61L2420/08

Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

公开(公告)号：US20200308440A1

公开(公告)日：2020-10-01

申请号：US16312448

申请日：2017-06-24

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Elise Lin Cheng ,  C. Allan Guymon ,  Marlan R. Hansen ,  Braden Leigh

IPC: C09D133/10 ,  C09D5/16 ,  C08K5/11 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C09D133/26 ,  A61L29/04 ,  A61L31/04 ,  A61L27/16 ,  C09D151/08

Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.