公开(公告)号：US20230293594A1

公开(公告)日：2023-09-21

申请号：US18135543

申请日：2023-04-17

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Steven A. GOLDMAN ,  Maiken NEDERGAARD

IPC: A61K35/30 ,  A61P25/18 ,  A61K31/495 ,  C12N5/0735 ,  C12N5/074

CPC classification number: A61K35/30 ,  A61K31/495 ,  A61P25/18 ,  C12N5/0606 ,  C12N5/0696 ,  A61K9/0019

Abstract: The present disclosure is directed to a method of treating a neuropsychiatric disorder. This method involves selecting a subject having the neuropsychiatric disorder and administering to the selected subject a preparation of glial progenitor cells at a dosage effective to treat the neuropsychiatric disorder in the subject. Another aspect of the disclosure is directed to a method of treating a neuropsychiatric disorder that includes selecting a subject having the neuropsychiatric disorder and administering, to the selected subject, a potassium (K+) channel activator at a dosage effective to restore normal brain interstitial glial K+ levels in the selected subject and treat the neuropsychiatric disorder is also disclosed.